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Studies of cultured neuronal networks using light activated ion channels and pumps

dc.contributor.advisorWolf, Fred Prof. Dr.de
dc.contributor.authorEl Hady, Ahmedde
dc.date.accessioned2013-02-26T10:18:16Zde
dc.date.available2013-02-26T10:18:16Zde
dc.date.issued2013-02-26de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-000E-0105-9de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3747
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc570de
dc.titleStudies of cultured neuronal networks using light activated ion channels and pumpsde
dc.typedoctoralThesisde
dc.contributor.refereeStühmer, Walter Prof. Dr.de
dc.date.examination2012-10-10de
dc.description.abstractengIn the presented thesis work, an “Optical Network Electrophysiology “ system that combines optical stimulation using optogenetic tools and multisite neuronal recording using microelectrode arrays was developed and its applicability to address questions related to neuronal network dynamics was demonstrated. The system was used to modify the intrinsic collective dynamics of a cultured neuronal network potentially maximizing spike synchronization using mild whole field photostimulation. It offers an attractive alternative to stimulation paradigms that externally control neuronal networks. Another application of the system was to drive neurons in a naturalistic in-vivo like fashion where fluctuating light waveforms where used to put neurons in “fluctuation driven regime”. This regime is crucial to characterize basic computational properties of neurons such as frequency-input curves, spike triggered average and correlation gain.de
dc.contributor.coRefereeGeisel, Theo Prof. Dr.de
dc.subject.engOptogeneticsde
dc.subject.engMultielectrode arraysde
dc.subject.engNetwork electrophysiologyde
dc.subject.engFluctuation driven regimede
dc.subject.engNetwork-level plasticityde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-000E-0105-9-3de
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)de
dc.subject.gokfullBiologie (PPN619462639)de
dc.identifier.ppn737347368de


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