Ruthenium-Catalyzed Synthesis of Biaryls through C–H Bond Functionalizations
von Emelyne Diers
Datum der mündl. Prüfung:2013-10-14
Erschienen:2013-11-15
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Ulf Diederichsen
Dateien
Name:Dissertation - Emelyne Diers.pdf
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Format:PDF
Zusammenfassung
Englisch
The main focus of this work was the development of new methodologies for the efficient and step-economical synthesis of biaryls cores by direct arylation through direct C–H bond cleavage. In this aim, the first ruthenium-catalyzed direct arylation of arenes bearing a removable directing group was achieved. Furthermore, a step-economical synthesis to the antihypertensive Valsartan was successful with ruthenium as a catalyst. Afterwards, we developed a new bidentate directing group for the efficient ruthenium-catalyzed direct arylation of amides.
Keywords: catalysis; C–H bond functionalization; ruthenium; sustainable chemistry; biaryls; Valsartan