s100β und Homocystein im Serum von stationär behandelten alkoholabhängigen Patienten als Verlaufsvariablen des akuten Alkoholentzugssyndroms

Neumann, Karoline

dc.contributor.advisor	Wedekind, Dirk PD Dr.
dc.contributor.author	Neumann, Karoline
dc.date.accessioned	2014-01-21T08:48:36Z
dc.date.available	2014-01-28T23:50:04Z
dc.date.issued	2014-01-21
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5DFF-C
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4287
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	s100β und Homocystein im Serum von stationär behandelten alkoholabhängigen Patienten als Verlaufsvariablen des akuten Alkoholentzugssyndroms	de
dc.type	doctoralThesis	de
dc.title.translated	Serum levels of S100B and homocysteine in alcohol-addicted inpatients as variables of the acute alcohol withdrawal syndrome	de
dc.contributor.referee	Bachmann, Cornelius G. PD Dr.
dc.date.examination	2014-01-21
dc.description.abstracteng	Elevations of serum homocysteine levels are a consistent finding in alcohol addiction. Serum S100B levels are altered in different neuropsychiatric disorders but not well investigated in alcohol withdrawal syndrome. Because of the close connection of S100B to ACTH and glutamate secretion, that both are involved in neurodegeneration and symptoms of alcoholism, the relationship of S100B and homocysteine to acute withdrawal variables has been examined. 22 male and 9 female inpatients (mean age 46.9±8.7 years) with an ICD-10 diagnosis of alcohol addiction and without relevant affective comorbidity were examined on admission and after 24, 48, and 120 hours during withdrawal. S100B and homocysteine levels in serum were collected and the initial serum ethanol-levels. The severity of withdrawal symptoms (AWS-scale), applied withdrawal medication and duration of addiction were recorded. Serum S100B and homocysteine levels declined significantly (p<.05) during the study period. Both levels declined simultaneously with withdrawal syndrome severity. Females showed a trend to a more intense decline in serum S100B levels compared to males at day 5 (p=.06). Homocysteine levels displayed a negative relationship to applied amount of clomethiazole (p<.05) and correlated with age of onset of addiction. No withdrawal seizures were recorded during the trial. As it is known for homocysteine, S100B revealed to decline rapidly over withdrawal treatment in alcoholism. This effect is more pronounced in female patients. S100B could be of relevance in the neurobiology of alcohol withdrawal syndromes. It may be indirectly related to the stress level or glutamatergic activity during alcohol withdrawal.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	Alkoholabhängigkeit	de
dc.subject.ger	s100β	de
dc.subject.ger	Alkoholentzug	de
dc.subject.ger	Homocystein	de
dc.subject.eng	alcohol addiction	de
dc.subject.eng	homocysteine	de
dc.subject.eng	s100β	de
dc.subject.eng	withdrawal	de
dc.subject.eng	S100B	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5DFF-C-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Psychiatrie (PPN619876344)	de
dc.description.embargoed	2014-01-28
dc.identifier.ppn	776772007

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