Vergleichende Untersuchungen der Nasenflora von Probanden aus Ghana und Deutschland

Seeba, Hannah

dc.contributor.advisor	Groß, Uwe Prof. Dr.
dc.contributor.author	Seeba, Hannah
dc.date.accessioned	2015-08-12T08:40:33Z
dc.date.available	2015-08-19T22:50:05Z
dc.date.issued	2015-08-12
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-6079-6
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5186
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Vergleichende Untersuchungen der Nasenflora von Probanden aus Ghana und Deutschland	de
dc.type	doctoralThesis	de
dc.title.translated	Comparing characteristics of nasal flora of subjects from Ghana and Germany	de
dc.contributor.referee	Laskawi, Rainer Prof. Dr.
dc.date.examination	2015-08-12
dc.description.abstracteng	Purpose: This study aims at comparing the composition and resistance patterns of nasal flora by analyzing swab samples of subjects living in rural Ghana and subjects living in Germany. Special attention is paid to the various reasons for the development of antibiotic resistances, MRSA prevalence, and the nasal cavity resembling a reservoir of potentially pathogenic bacteria. Methods: 200 nasal swabs of patients of a Ghanaian polyclinic and 101 nasal swabs of healthy German volunteers were examined for bacterial growth and antibiotic resistances. 17 of the swabs taken from German subjects were sterile and were therefore not included in the statistics. Results: 17.5% of the swabs from of Ghanaian subjects and 57.1% of the swabs of the German volunteers showed exclusively apathogenic bacterial growth. Potentially pathogenic bacteria grew in 82.5% of the samples of Ghanaian patients and in 36.6% of the German subjects’ samples. MRSA was found in 3.0% of all swabs from of Ghanaians (accounting for 17.7% of all Staphylococcus aureus strains in this group). None of the Germans’ swabs showed MRSA growth. In 37.0% of the samples of Ghanaians and in 6.0% of the samples of German volunteers enterobacteriaceae were detected. Significant differences in antibiotic resistance patterns were found for chloramphenicol, oxacillin, erythromycin, and lincosamides. These were particularly obvious in staphylococci which, due to higher prevalence, accounted for higher significance. 43.5% of Ghanaian patients and only 7.1% of German volunteers received antibiotic treatment in the four weeks prior to swabbing. Only 22 of the Ghanaian patients saw a doctor for symptoms of respiratory tract infections; of these, 16 patients (72.7%) were populated with pathogenic bacteria (i.e. less than the average of all Ghanaian patients). Conclusion: Taking into account the differences in medical treatment and living conditions, a possible connection can be established between the nasal bacterial population and the antibiotic resistances in these bacteria. Chloramphenicol (rarely used in Germany anymore) showed a major variation in the two groups. With bacterial resistances becoming a more threatening issue, it seems crucial to thoroughly evaluate when and how to treat patients with antibiotics. Therefore, it is necessary to improve education about understanding the interrelation of treatment and resistance in both patients and medical staff.	de
dc.contributor.coReferee	Schön, Margarete Prof. Dr.
dc.subject.ger	Nasenflora	de
dc.subject.ger	Antibiotikaresistenzen	de
dc.subject.ger	Chloramphenicol	de
dc.subject.ger	Resistenzentwicklung	de
dc.subject.ger	Ghana	de
dc.subject.ger	Antibiotikatherapie	de
dc.subject.ger	Atemwegserreger	de
dc.subject.eng	nasal bacterial flora	de
dc.subject.eng	antibiotic resistance	de
dc.subject.eng	chloramphenicol	de
dc.subject.eng	resistance development	de
dc.subject.eng	antibiotic treatment	de
dc.subject.eng	MRSA	de
dc.subject.eng	Ghana	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-6079-6-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Medizinische Virologie	de
dc.subject.gokfull	Medizinische Mykologie	de
dc.subject.gokfull	Medizinische Mikrobiologie	de
dc.subject.gokfull	Infektionskrankheiten	de
dc.subject.gokfull	Hygiene	de
dc.subject.gokfull	Tropenmedizin - Allgemein- und Gesamtdarstellungen	de
dc.description.embargoed	2015-08-19
dc.identifier.ppn	833175386

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Human- und Zahnmedizin [2877]

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