| dc.contributor.advisor | Ackermann, Lutz Prof. Dr. | |
| dc.contributor.author | Lackner, Sebastian | |
| dc.date.accessioned | 2016-07-15T09:48:33Z | |
| dc.date.available | 2017-01-01T23:50:12Z | |
| dc.date.issued | 2016-07-15 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0028-87C8-1 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5738 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5738 | |
| dc.language.iso | eng | de |
| dc.publisher | Niedersächsische Staats- und Universitätsbibliothek Göttingen | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 540 | de |
| dc.title | Nickel-Catalyzed Secondary Alkylations and Fluoroalkylations via C–H Activation | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Ackermann, Lutz Prof. Dr. | |
| dc.date.examination | 2016-06-29 | |
| dc.description.abstracteng | In the past several decades, transition metal-catalyzed cross-coupling reactions proved to be of utmost importance within organic synthesis. However, required prefunctionalization of substrates remained as a major disadvantage of this methodology. A solution to this are direct C–H functionalizations, which have emerged in recent years as a viable synthetic tools. The focus within this thesis was on the development of atom- and step-economic nickel-catalyzed C–H alkylation reactions utilising challenging, unactivated alkyl halides with β-hydrogen or β-fluorine atoms. In the first part, a protocol for the direct C–H secondary alkylation of benzamides under bidentate assistance was devised for a variety of alkyl bromides. Second, investigations on a novel trifluoroethylation were conducted. Third, focus was shifted to utilising simpler and biologically relevant directing groups for direct C–H secondary alkylation. For this a simple catalytic system was developed for the efficient ortho-alkylation of aniline derivatives. The involved nickelacycle is presumed to be an unusual six-membered metalacycle. Finally, the novel C–H trifluoroethylation was applied to aniline derivatives as well. | de |
| dc.contributor.coReferee | Koszinowski, Konrad Prof. Dr. | |
| dc.subject.eng | Nickel | de |
| dc.subject.eng | C–H Activation | de |
| dc.subject.eng | Homogeneous Catalysis | de |
| dc.subject.eng | Alkylation | de |
| dc.subject.eng | Trifluoroethylation | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0028-87C8-1-9 | |
| dc.affiliation.institute | Fakultät für Chemie | de |
| dc.subject.gokfull | Chemie (PPN62138352X) | de |
| dc.description.embargoed | 2017-01-01 | |
| dc.identifier.ppn | 86319365X | |