Der Effekt von CD16-positiven und CD16-negativen Monozyten auf die Arterio- und Angiogenese nach muriner Hinterlaufischämie

Bernhardt, Markus

dc.contributor.advisor	Czepluch, Frauke Stefanie PD Dr.
dc.contributor.author	Bernhardt, Markus
dc.date.accessioned	2018-08-07T06:10:40Z
dc.date.available	2018-08-16T22:50:03Z
dc.date.issued	2018-08-07
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E46A-6
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6993
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6993
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Der Effekt von CD16-positiven und CD16-negativen Monozyten auf die Arterio- und Angiogenese nach muriner Hinterlaufischämie	de
dc.type	doctoralThesis	de
dc.title.translated	The effect of CD16-positive and CD16-negative monocytes on arterio and angiogenesis after murine hindlimb-ischemia	de
dc.contributor.referee	Oppermann, Martin Prof. Dr.
dc.date.examination	2018-08-09
dc.description.abstracteng	Neovascularization is one of the most important mechanisms for compensation of acute ischemic events. In this topic, monocytes play a key role in new vessel growth like arteriogenesis and angiogenesis. They can be divided into CD16+- and CD16--subsets. It is not known so far, which one of the monocyte subsets is responsable for the development of new arteries of pre-existing capillaries and we do not know how they influence this process. So it was the aim of this study to investigate the differences between monocyte subsets in arterio- and angiogenesis. Therefor we used the murine hindlimb-ischemia-model, analyzed the reperfusion rate via Laser-Doppler-imaging about 28 days and examined the differences of new vessel formation depending on monocyte subsets with and without Leptin-stimulation via immunofluorescence. Our results show that the count of arteries is reduced and the cross-sectional area of smooth muscle layer is bigger after application of CD16+-mo compared to CD16--mo. Further, after application of Leptin-stimulated monocyte subsets the count of capillaries was reduced as well.	de
dc.contributor.coReferee	Meyer, Thomas Prof. Dr.
dc.subject.eng	Monocytes	de
dc.subject.eng	Arteriogenesis	de
dc.subject.eng	Angiogenesis	de
dc.subject.eng	hindlimb-ischemia	de
dc.subject.eng	Laser-Doppler-Imaging	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E46A-6-2
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Kardiologie (PPN619875755)	de
dc.description.embargoed	2018-08-16
dc.identifier.ppn	1028464932

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Human- und Zahnmedizin [2877]

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