Evaluation eines Riechtests im Rahmen der De-Novo-Parkinson-Kassel-Studie

Hippel, Sonja

dc.contributor.advisor	Mollenhauer, Brit Prof. Dr.
dc.contributor.author	Hippel, Sonja
dc.date.accessioned	2018-11-01T09:39:21Z
dc.date.available	2018-11-28T23:50:05Z
dc.date.issued	2018-11-01
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E4E7-E
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7107
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Evaluation eines Riechtests im Rahmen der De-Novo-Parkinson-Kassel-Studie	de
dc.type	doctoralThesis	de
dc.title.translated	Evaluation of olfactory testing part of the De-Novo-Parkinson-Kassel-study	de
dc.contributor.referee	Niebert, Marcus PD Dr.
dc.date.examination	2018-11-21
dc.description.abstracteng	Parkinsons’s disease is one of the most common neurodegenerative disorders. Currently only the symptoms can be treated, but no neuroprotective therapy is available. In order to develop necessary medication we need further information about the beginning of the disease itself, the course of the disease as well as about non-motor symptoms, being typical for Parkinson’s disease. This dissertation evaluates the results of the De-Novo-Parkinson-Kassel-study putting special focus on olfactory testing with Sniffin’ Sticks. The study consists of 117 patients and 100 healthy controls. The groups are being compared by different tests focused on non-motor symptoms, e.g. olfactory loss, depression, sleep disability, cognitive impairment and life quality. The tests were conducted at two different dates. When comparing the baseline testing with the follow-up testing 24 months later, the results of our statistical analysis show significant differences between the groups. Especially the results of olfactory testing show a clear deterioration of olfactory abilities during the course of the disorder. Our findings lead to the conclusion that hyposmia is a valid symptom for Parkinson’s disease. Using hyposmia as a part of a biomarker could thus help detecting patients with Parkinson’s disease at an earlier, premotor stage.	de
dc.contributor.coReferee	Schön, Margarete Prof. Dr.
dc.subject.ger	Morbus Parkinson	de
dc.subject.ger	sniffin sticks	de
dc.subject.ger	De-Novo-Parkinson-Kassel-Studie	de
dc.subject.ger	De novo Parkinson	de
dc.subject.ger	Riechtest	de
dc.subject.ger	prämotorisch	de
dc.subject.eng	parkinsons disease	de
dc.subject.eng	sniffin sticks	de
dc.subject.eng	de novo parkinson	de
dc.subject.eng	de-novo-parkinson-kassel-study	de
dc.subject.eng	olfactory testing	de
dc.subject.eng	premotor	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E4E7-E-7
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.embargoed	2018-11-28
dc.identifier.ppn	1039245153

Dateien

Name:Dissertation S. Hippel.pdf

Größe:3.639Mb

Format:PDF

Öffnen

Name:: Dissertation S. Hippel.pdf
Größe:: 3.639Mb
Format:: PDF

Öffnen

Das Dokument erscheint in:

Human- und Zahnmedizin [2878]

Zur Kurzanzeige