Einfluss der medikamentösen Präkonditionierung auf den Ischämie-/Reperfusionsschaden nach orthotoper Lebertransplantation im Rattenmodell
Influence of MDDP-Preconditioning on Ischämia/Reperfusion injury in a rat liver transplantation model
von Rian Urbach
Datum der mündl. Prüfung:2018-11-20
Erschienen:2018-11-20
Betreuer:Prof. Dr. Otto Kollmar
Gutachter:Prof. Dr. Sabine Mihm
Gutachter:Prof. Dr. Martin Oppermann
Dateien
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Zusammenfassung
Englisch
Due to the high discrepancy between supply and demand of organ donations, there is a major organ shortage. There are different ways in which to recover organs, especially those which are marginal. These particular organs are more susceptible to damage and rejection during and after a transplant. This damage can be minimized. This study concerns itself with the liver as an compromised organ due to fatty deposits. The growing percentage of obesity in industrialized nations has a direct correlation on the prevelance of NASH and cirrhosis in the population. It is of special interest for the future to see if previously damaged livers can be harvested and used to increase the number of livers in the donation pool. Referencing a study by Moussavian et. al 2011, this shows that a MDDP-preconditioned ischemia-reperfusion, or deoxygenation, injury can be mitigated with cold ischemia. Our study evaluated 162 liver transplants from men, on whom the Sprangue-Dawley processed was performed. In addition, we evaluated to what extent the MDDP-preconditioning ischemia-reperfusion injuries on livers with and without fatty deposits in animal subjects worked. Drugs used for the preconditioning of organs included curcumin, Simvastatin, N-Acetylcystein, Erythropoietin, Pentoxiphyllin, melatonin, glycine, and Methylprednisolon. These drugs were given to the donor animal before extraction of the organ. Neither livers treated with or without the statin preconditioning drugs produced a better outcome from the transplant.
Keywords: rat preconditioning; liver transplantation