dc.contributor.advisor | Gruber, Oliver Prof. Dr. | |
dc.contributor.author | Said, Jasmin | |
dc.date.accessioned | 2020-05-26T09:14:43Z | |
dc.date.available | 2020-06-06T22:50:03Z | |
dc.date.issued | 2020-05-26 | |
dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-13AB-5 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-7993 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Decis State - Dysfunktionen neuronaler Mechanismen der Impulskontrolle bei Suchterkrankung –eine funktionell-kernspintomographische Untersuchung von Patienten mit langjähriger Alkoholabhängigkeit | de |
dc.type | doctoralThesis | de |
dc.title.translated | DECIS-State: Dysfunctional neural mechanisms of impulse control of addiction- A functional neuroimaging study of patients with longstanding alcohol addiction | de |
dc.contributor.referee | Wilke, Melanie Prof. Dr. | |
dc.date.examination | 2020-05-27 | |
dc.description.abstracteng | <p>The mesolimbic dopamine system plays a central role in the development of addiction. Some of its areas enable quick (impulsive) desires for preferred or conditioned stimuli. On the other hand, pre-frontal areas, which are disturbed in addictive patients, suppress impulsive behavior in favor of a long-term goal.</p>
<p>
A functional magnetic resonance imaging with a DRD-Paradigm was used to investigate potential dysfunctions of neurofunctional systems of impulse control in patients with longstanding alcohol dependence.
</p><p>
17 patients and 15 controls were included in the clinical prospective study.
</p><p>
As expected, the abstinent alcoholics activated the areas of the mesolimbic dopamine system during presentation of alcoholic stimuli. In the Desire context, however, the patients showed a reduced activation of these areas. Together, these findings point to a higher salience of alcohol-associated stimuli. Moreover, it also took the patients longer to refuse alcoholic stimuli. Finally, in Reason-context the abstinent alcoholics showed a top-down suppression effect to alcoholic stimuli in favor of a long-term goal. We interpret this finding as a successful therapeutic effect after inpatient treatment.
</p> | de |
dc.subject.eng | Impulse control | de |
dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-13AB-5-8 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Psychiatrie (PPN619876344) | de |
dc.description.embargoed | 2020-06-06 | |
dc.identifier.ppn | 1698857934 | |