dc.contributor.advisor | Kaganovich, Daniel Prof. Dr. | |
dc.contributor.author | Pattabiraman, Sundararaghavan | |
dc.date.accessioned | 2020-12-10T15:41:05Z | |
dc.date.available | 2020-12-10T15:41:05Z | |
dc.date.issued | 2020-12-10 | |
dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-151B-6 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8320 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8320 | |
dc.language.iso | eng | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 570 | de |
dc.title | Vimentin protects differentiating stem cells from stress | de |
dc.type | doctoralThesis | de |
dc.contributor.referee | Göpfert, Martin Prof. Dr. | |
dc.date.examination | 2019-12-12 | |
dc.description.abstracteng | Vimentin is the first cytoplasmic intermediate filament to be expressed in mammalian cells during early differentiation, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is thought to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by directly binding aggregates and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response. | de |
dc.contributor.coReferee | Outeiro, Tiago Fleming Prof. Dr. | |
dc.subject.eng | Vimentin, Intermediate Filaments, Aggregation, Stress Granules, RNP Granules, Asymmetric Inheritance, Aging, Differentiation, Embryonic Stem Cells | de |
dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-151B-6-3 | |
dc.affiliation.institute | Biologische Fakultät für Biologie und Psychologie | de |
dc.subject.gokfull | Biologie (PPN619462639) | de |
dc.identifier.ppn | 1742565077 | |