Einfluss des Integrins α E (CD103) auf das allergische Kontaktekzem bei Mäusen
Influence of the integrin α E (CD103) on the allergic contact dermatitis in mice
von Fiona Brunnert
Datum der mündl. Prüfung:2021-07-20
Erschienen:2021-07-15
Betreuer:Prof. Dr. Michael P. Schön
Gutachter:Prof. Dr. Lutz Walter
Gutachter:Prof. Dr. Ralf Dressel
Dateien
Name:Brunnert, Dissertation final 07.2021.pdf
Size:1.55Mb
Format:PDF
Zusammenfassung
Englisch
Allergic contact dermatitis is a dermatologic disease that affects both children and adults and has a high prevalence due to the variety of potential contact allergens. In most cases, it is based on a late-type allergic reaction. The late-type reaction is a cell-mediated immune response that occurs in two phases: the sensitization phase and the effector phase. Immunologically, dendritic cells as antigen-presenting cells, as well as T lymphocytes as effector and regulatory cells, play a crucial role. Integrins are an essential component in cell interactions. CD103 designates the αE-chain of integrin αEβ7, and is expressed primarily on intraepithelial lymphocytes and dendritic cells. The only ligand known to date is E-cadherin, which in turn is expressed by epithelial cells, such as keratinocytes and Langerhans cells. To date, CD103 is known to be involved in the localization and recruitment of T cells to the epithelium in its role as an adhesion receptor. Similarly, it serves to maintain the balance of effector cells and regulatory T cells in tissues, thus playing an essential role in immune regulation. In this work, we investigated the role of CD103 in the different phases of allergic contact dermatitis. For this purpose, the CHS mouse model was used and wild-type mice were compared with CD103-deficient mice. The results of this work indicate that CD103 on dendritic cells probably plays a rather minor role in the pathogenesis of allergic contact eczema. Rather, T-cell function appears to be influenced by CD103 expression. It should be emphasized that CD103-deficient CD8+ T cells could induce an enhanced immune response.
Keywords: integrin; CD103; allergic contact dermatitis