# Browsing by Issue Date

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• (2021-11-16)
The Calar Alto high-Resolution search for M dwarfs with Exo-earths with Near-infrared and optical Echelle Spectrographs (CARMENES) has been searching and finding planets for five years by looking for periodic Doppler-shift ...
• (2021-11-16)
Superstructures fabricated from carbohydrates and their derivatives hold an immense promise for the application in diverse fields. However, still many understudied problems challenge us, such as the roles of backbones and ...
• (2021-11-16)
In 2012, a scalar boson was found at CERN that is consistent with the properties of the Higgs boson predicted by the Standard Model (SM) of particle physics. Some theories, in particular supersymmetric models, also predict ...
• (2021-11-15)
The nervous system is developed under the regulation of growth and guidance cues. This process is highly dynamic and tightly regulated by the composition, concentration and timely presence of different signalling molecules. ...
• (2021-11-15)
The present work aims to investigate mono-metallic cobalt and dysprosium complexes containing the S-N motive and put their potential as competitive single-molecule magnets (SMMs) into perspective. To this purpose, experimental ...
• (2021-11-15)
Within this thesis various nanohybrid systems constructed from metal nanocrystal cores and polymer shells were specifically tailored towards distinct practical applications. The first part of this work addresses the ...
• (2021-11-15)
Lipid-peptide interactions are involved in many essential processes of living organisms, such as cell fusion or transport processes and are therefore, in the center of research interest. One efficient technique to analyze ...
• (2021-11-11)
In this thesis we study different questions on scalar curvatures. The first part is devoted to obstructions against existence of a (Riemannian) metric with positive scalar curvature on a closed manifold. The second ...
• (2021-11-11)
A significant and computationally most demanding part of molecular dynamics simulations is the calculation of long-range electrostatic interactions. Such interactions can be evaluated directly by the naïve pairwise summation ...
• (2021-11-11)
Based on the vowel inventory in the first syllable, the Balto-finnic languages can be divided into two groups: the southern (North and South Estonian, Votic and Livonian) with the back vowel õ [ɤ] and the northern (Finnish, ...
• (2021-11-11)
In 2004, a new cell death program called neutrophil extracellular trap (NET) formation (also termed NETosis) was described, in which neutrophil granulocytes, stimulated by pathogens, formed web-like structures from their ...
• (2021-11-11)
In this work, two transgenic mouse models were characterized that showed disruption either of presynaptic Ca2+-influx (CaVβ2) in inner hair cells or of the cochlear K+-cycle (Cx26) by targeted mutagenesis. Approaches of ...
• (2021-11-10)
Streptococcus pneumoniae and Escherichia coli are responsible for a wide variety of life-threatening infections such as pneumonia, sepsis, and meningitis. Multi-resistant pathogens are spreading more and more despite the ...
• (2021-11-10)
Problem: Clostridioides difficile infections (CDI) have emerged as the leading cause of hospital-acquired diarrhea. The disruption of physiological gut microbiota by consumption of antibiotics is one of the major risk ...
• (2021-11-09)
Dimerization of G-protein coupled receptors (GPCRs) has become a big field of research as there is increasing evidence that it has a huge impact on the signaling of receptors. In this work we focused on the group of ...
• (2021-11-09)
Background and purpose: Flat detector CT (FDCT) has been used as a peri-interventional diagnostic tool in numerous studies with mixed results regarding image quality and detection of intracranial lesions. We compared the ...
• (2021-11-09)
Acute graft-versus-host disease (aGvHD) is a common complication after allogeneic hematopoietic stem cell transplantation for which only limited therapeutic options are available. Numerous published studies have shown an ...
• (2021-11-09)
It is a major challenge to detect paroxysmal AF in patients with ischemic stroke. A number of studies addressing this question have been published, but the comparison of these clinical trials is complicated by different ...
• (2021-11-08)
Research concerning failure of inpatient psychotherapy in Germany is rare and affected by methodological problems. Consequently, there is a lack of results of multimodal studies assessing the frequency of nonresponse and ...
• (2021-11-08)
Aim: It was the aim of the study to compare the quality of single-cone root canal obturation following preparation with single-file or multiple-files technique using micro-computer-tomography. Materials and methods: ...
• (2021-11-05)
Dark matter is a hypothetical form of matter, which is thought to make up nearly $27\%$ of the contents in our Universe. An increasingly popular idea is that the dark matter could be composed of light (pseudo-)scalar ...
• (2021-11-04)
This cumulative dissertation examines the hedging effectiveness of satellite-based weather index insurance for both annual crops, such as rice and wheat, and also perennial olive trees and pine stands. Unlike traditional ...
• (2021-11-04)
In the last 60 years, maize production has increased worldwide, reaching 1.14 billion tons in 2018. Maize production in Europe and South America was about 110 and 130 million tons in 2018, respectively. The demand for ...
• (2021-11-04)
The aim of this study was to analyse if the erosion-protective potential of the salivary pellicle is different between female and male subjects. Bovine enamel and dentin specimens (each n = 3) were exposed to the oral ...
• (2021-11-04)
This dissertation is concerned with how information about the environment is represented by neural activity in the primate brain. More specifically, it contains several studies that explore the representation of visual ...
• (2021-11-04)
Estimating farmers’ supply responses to changes in framework conditions is important to inform decision-makers on the expected impacts on production volume as well as the resulting land-use shifts. Existing agricultural ...
• (2021-11-04)
Telomere length homeostasis is a prerequisite for cell viability. It is challenged through successive shortening, which is due to the “end-replication-problem”. This limits the cellular life span in multicellular organisms ...
• (2021-11-04)
Mixed cropping, the simultaneous cultivation of two or more coexisting crops in one field, is one possibility to increase biodiversity within farming systems. However, adoption of mixed cropping systems is challenging for ...
• (2021-11-04)
This thesis described the development of a novel, versatile microfluidic platform for studying the ionic mechanisms of vesicular neurotransmitter transporters in rodent synaptic vesicles (SVs). The level of filling of an ...
• (2021-11-03)
Introduction: Cardiovascular diseases play a leading role in the western industrial nations in terms of mortality, morbidity and economic costs. At the same time, the heart transplant is the only causal therapy for heart ...
• (2021-11-03)
Cortical processing of information is significantly influenced by inhibitory GABAergic Interneurons, although they only account for about 15-20% of all cortical neurons. Three main subpopulations can be distinguished based ...
• (2021-11-03)
The dimension subgroup problem and the Ore conjecture are two group theoretical problems. In this thesis, translations of these problems to Lie algebras are analyzed and partially solved.
• (2021-11-02)

Rheumatoid arthritis (RA) is associated with a significantly higher cardiovascular risk as compared to the general population. On the one hand it is caused by the inflammatory process, on the other hand it is the ...

• (2021-11-02)
In the management of osteoporosis the determination of fracture risk is essential for the indication of a specific antiosteoporotic treatment. Within Europe different scores are used for fracture risk prediction. We used ...
• (2021-11-02)
The pulmonary epithelia of patients with COPD show an increased expression of TP53 and have higher proliferation and apoptosis rates, compared to healthy individuals. Although, Trp53-deficient mouse lung have higher ...
• (2021-11-02)
In many traumatic and neurodegenerative disorders of the central nervous system, axonal degeneration is a central and early pathophysiological feature. Since the regenerative response of injured neurons is severely hampered ...
• (2021-10-28)
Anthropogenic global warming is creating new challenges for forest management in many parts of the world. One vital aspect is the choice of tree species and whether to cultivate monospecific or mixed timber plantations. ...
• (2021-10-28)
While laser frequency combs (LFCs) are in principle ideal calibration light sources for high resolution spectrographs, they are still not regularly used. This is not only due to high cost and maintenance, but also persistent ...
• (2021-10-28)
A mechanically stressed film can cause a bending of the underlying substrate. Usually, the substrate deforms elastically, but in special cases a plastic or viscous deformation can be observed. Such deformations are mostly ...
• (2021-10-26)
In this retrospective single-centre study, clinical and histological prognostic factors for the survival of 83 patients with relapsed / refractory aggressive B-cell lymphoma after allogeneic stem cell transplantation between ...
• (2021-10-26)
Neurotransmitter release is a key step that enables information flow between the pre- and post-synapse. However, regulation of the neurotransmitter release remains an intricate and widely unexplored matter despite recent ...
• (2021-10-26)
Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ...
• (2021-10-26)
Objective: The aim of this study is to provide an overview of the management of acute aneurysmal subarachnoid haemorrhage (SAH) and more specifically of the management of ventilation and sedation therapy (VST) in the ...
• (2021-10-26)
Devices for interventional atrial septal defect closure are meant to remain in patient’s bodies for several years. Up until now little is known about the long-term biocompatibility. The main goal of this work was ...
• (2021-10-26)
This thesis demonstrates how colloidal probe force spectroscopy, in connection with reconstituted biological model systems and theoretical models, allows us to investigate and understand the behavior of a wide variety ...
• (2021-10-25)
In this doctoral thesis, the time course of axonal damage and the effect of glutamatergic and purinergic receptor antagonists on acute axon pathology were investigated in the focal experimental NMO rat model for the first ...
• (2021-10-25)
Since hydrocarbons are omnipresent structural units in organic compounds, the utilization of C–H bonds of hydrocarbons has great potential. Thereby, organic chemists have had utmost interests in the transformation of ...
• (2021-10-22)
Fingerprints feature a ridge line pattern inducing an undirected orientation field (OF) which usually features some singularities. Ridges vary in width, inducing a moderately varying ridge frequency (RF). In fingerprint ...
• (2021-10-22)
Approaches to exploit the proximity of the two-dimensional material graphene to certain materials in order to specifically tune graphene’s properties start to emerge. However, to turn these approaches into truly beneficial ...
• (2021-10-22)
Noonan syndrome is a multisystemic developmental disorder and is characterized by variable symptoms such as facial dysmorphisms, short stature, webbing of the neck and mild intellectual disability. The most severe clinical ...
• (2021-10-21)
In all extant organisms adenosine triphosphate (ATP) is the energy carrier and transmitter of free energy from exergonic to endergonic processes. Since ATP is a complex molecule, it was unlikely available on prebiotic ...
• (2021-10-21)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, characterized by demyelination and axonal damage as well as neuronal degeneration. Oxygen-derived free radicals are an important ...
• (2021-10-21)
Auxin is a major plant growth regulator whose interaction with cell wall properties is central to its role. Efflux carriers of this phytohormone of the PIN-FORMED family (PIN) respond to the mechanical state of the tissue. ...
• (2021-10-21)
During the global COVID-19 pandemic, the needs and benefits of fast and specific analytical tools became apparent to everyone. In particular, advances in nanotechnology promise novel healthcare diagnostics, like the ...
• (2021-10-19)
In this thesis, structures defined via modular operads and properads are generalized to their non-commutative analogs. We define the connected sum for modular operads. This way we are able to construct the graded commutative ...
• (2021-10-19)
Phosphorus (P) is an essential element for plant nutrition because it is required for many essential biomolecules such as nucleotides, membrane lipids and ATP. Plants take up P as inorganic phosphate (Pi) from soil solutions. ...
• (2021-10-19)
Polyploidy, the presence of two or more full genomic complements, repeatedly occurs across the tree of life. In plants, not only the economic but particularly the evolutionary importance is overwhelming. Polyploidization ...
• (2021-10-19)
The compound water exhibits a variety of unique properties which are indispensable for many processes in animate and inanimate nature. These properties do not arise from a single water molecules but from the strong anisotropic ...
• (2021-10-19)
Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific ...
• (2021-10-19)
In eukaryotes, transcriptional gene regulation is controlled by a set of transcription factors (TFs) and co-factors. Most TFs bind to specific DNA sequences. These binding sites are called transcription factor binding ...