A Functional Characterisation of Drosophila Chordotonal Organs

Wiek, Robert Jago

dc.contributor.advisor	Göpfert, Martin Prof. Dr.	de
dc.contributor.author	Wiek, Robert Jago	de
dc.date.accessioned	2013-06-27T08:35:50Z	de
dc.date.available	2013-06-27T08:35:50Z	de
dc.date.issued	2013-06-27	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0001-B986-9	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3910
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	570	de
dc.title	A Functional Characterisation of Drosophila Chordotonal Organs	de
dc.type	doctoralThesis	de
dc.contributor.referee	Göpfert, Martin Prof. Dr.	de
dc.date.examination	2013-06-21	de
dc.description.abstracteng	Functional properties of the Drosophila FCO (femoral chordotonal organ) can be dissected by use of the Gal4-UAS system in combination with transcuticular in vivo Calcium imaging. As sinusoidal stimulation at relative small stimulus amplitudes elicited changes in intracellular ionic calcium (Ca2+) concentration in the FCO, the effect of substrate vibration on Drosophila walking behaviour was proposed. But lately developed fly tracking software for high-throughput ethomics (Branson et al., 2009) showed that substrate vibrations have no specific effect on Drosophila walking behaviour. Instead present evidence suggests that Drosophila compensates for substrate vibration by detection via the FCO and therefore is able to control its body posture. A modification of transcuticular in vivo Calcium imaging was used to locate the neuronal activity region of Inactive, a protein involved in Drosophila hearing and a mechanotransduction channel candidate. Here I show that Inactive mutants still respond to sound like stimulation with ciliary calcium currents.	de
dc.contributor.coReferee	Fiala, André Prof. Dr.	de
dc.contributor.thirdReferee	Büschges, Ansgar Prof.Dr.	de
dc.subject.eng	FCO	de
dc.subject.eng	JO	de
dc.subject.eng	TRP	de
dc.subject.eng	TRPV	de
dc.subject.eng	inactive	de
dc.subject.eng	substrate vibrations	de
dc.subject.eng	mechanotransduction	de
dc.subject.eng	auditory transduction of sound	de
dc.subject.eng	Calcium imaging	de
dc.subject.eng	Cameleon 2.1	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0001-B986-9-9	de
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	750586451	de

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GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1169]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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