Die Bedeutung von Reelin beim Neuroblastom

The importance of Reelin in Neuroblastoma

by Johanna Fröhlich
Doctoral thesis
Date of Examination:2013-07-08
Date of issue:2013-07-05
Advisor:Prof. Dr. Jörg Wilting
Referee:Prof. Dr. Dieter Kube
Referee:Prof. Dr. Patricia Virsik-Köpp
Persistent Address: http://dx.doi.org/10.53846/goediss-3922

 

 

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Abstract

English

Neurblastoma is a malignant tumor of early childhood. Its heterogeneity is reflected in its biological properties as well as clinical outcome. In this theses work, I have investigated the function of reelin, an extracellular glycoprotein with neuronal guidance capacity in the brain, for its impact on neuroblastoma progression and metastasis. I found that neuroblastoma cells have most likely abberrant reelin or reelin receptor expression. This leeds to insensitivity to reelin, which may provide a stop signal in normal development. Therefore the loss of reelin or non-functional reelin signalling may promote progression and metastasis of neuroblastoma.
Keywords: Reelin; Neuroblastoma
 
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