dc.contributor.advisor | Wilting, Jörg Prof. Dr. | de |
dc.contributor.author | Fröhlich, Johanna | de |
dc.date.accessioned | 2013-07-05T09:49:19Z | de |
dc.date.available | 2013-07-15T22:50:05Z | de |
dc.date.issued | 2013-07-05 | de |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0001-BAA8-4 | de |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-3922 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Die Bedeutung von Reelin beim Neuroblastom | de |
dc.type | doctoralThesis | de |
dc.title.translated | The importance of Reelin in Neuroblastoma | de |
dc.contributor.referee | Kube, Dieter Prof. Dr. | de |
dc.date.examination | 2013-07-08 | de |
dc.description.abstracteng | Neurblastoma is a malignant tumor of early childhood. Its heterogeneity is reflected in its biological properties as well as clinical outcome. In this theses work, I have investigated the function of reelin, an extracellular glycoprotein with neuronal guidance capacity in the brain, for its impact on neuroblastoma progression and metastasis. I found that neuroblastoma cells have most likely abberrant reelin or reelin receptor expression. This leeds to insensitivity to reelin, which may provide a stop signal in normal development. Therefore the loss of reelin or non-functional reelin signalling may promote progression and metastasis of neuroblastoma. | de |
dc.contributor.coReferee | Virsik-Köpp, Patricia Prof. Dr. | de |
dc.subject.eng | Reelin | de |
dc.subject.eng | Neuroblastoma | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BAA8-4-7 | de |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Pädiatrie / Neonatologie / Kinderchirurgie - Allgemein- und Gesamtdarstellungen (PPN619876093) | de |
dc.description.embargoed | 2013-07-15 | de |
dc.identifier.ppn | 751241644 | de |