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Die Bedeutung von Reelin beim Neuroblastom

dc.contributor.advisorWilting, Jörg Prof. Dr.de
dc.contributor.authorFröhlich, Johannade
dc.date.accessioned2013-07-05T09:49:19Zde
dc.date.available2013-07-15T22:50:05Zde
dc.date.issued2013-07-05de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0001-BAA8-4de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3922
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleDie Bedeutung von Reelin beim Neuroblastomde
dc.typedoctoralThesisde
dc.title.translatedThe importance of Reelin in Neuroblastomade
dc.contributor.refereeKube, Dieter Prof. Dr.de
dc.date.examination2013-07-08de
dc.description.abstractengNeurblastoma is a malignant tumor of early childhood. Its heterogeneity is reflected in its biological properties as well as clinical outcome. In this theses work, I have investigated the function of reelin, an extracellular glycoprotein with neuronal guidance capacity in the brain, for its impact on neuroblastoma progression and metastasis. I found that neuroblastoma cells have most likely abberrant reelin or reelin receptor expression. This leeds to insensitivity to reelin, which may provide a stop signal in normal development. Therefore the loss of reelin or non-functional reelin signalling may promote progression and metastasis of neuroblastoma.de
dc.contributor.coRefereeVirsik-Köpp, Patricia Prof. Dr.de
dc.subject.engReelinde
dc.subject.engNeuroblastomade
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0001-BAA8-4-7de
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullPädiatrie / Neonatologie / Kinderchirurgie - Allgemein- und Gesamtdarstellungen (PPN619876093)de
dc.description.embargoed2013-07-15de
dc.identifier.ppn751241644de


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