Modell der Bildung und Stabilität von Adhäsionsclustern in biologischen Membranen

Sunnick, Eva Maria

dc.contributor.advisor	Janshoff, Andreas Prof. Dr.
dc.contributor.author	Sunnick, Eva Maria
dc.date.accessioned	2013-08-22T08:22:00Z
dc.date.available	2013-08-22T08:22:00Z
dc.date.issued	2013-08-22
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0001-BB24-2
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4004
dc.language.iso	deu	de
dc.publisher	Niedersächsische Staats- und Universitätsbibliothek Göttingen	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	540	de
dc.title	Modell der Bildung und Stabilität von Adhäsionsclustern in biologischen Membranen	de
dc.type	doctoralThesis	de
dc.title.translated	Model of the formation and stability of adhesion clusters in biological membranes	de
dc.contributor.referee	Janshoff, Andreas Prof. Dr.
dc.date.examination	2013-08-19
dc.description.abstracteng	Cellular adhesion is pivotal in cell development, tissue formation and motility. The orchestration of cellular adhesion is an intricate process that involves a multitude of specialized proteins but at the same time follows a simple physical plan. Adhesion is based on non-covalent interactions predominantly between transmembrane proteins and the extracellular matrix. Most eukaryotic cells are able to create two-dimensional assemblies of integrins, so called focal adhesion clusters, which they use to stick to the substrate and collect information about the environmental properties. Integrins are intracellulary bound to the cytoskeleton, so that the adhesion process establishes an intricate interplay with signal transduction cascades. The clustering of those weak-interactions enable a cell to quickly respond to a changing environment and to create strong, long-lasting contacts surviving the finite-lifetime of the weak bonds. It is still not totally known why cells create clusters of bonds to adhere on a substrate. The question wether integrin clustering can be mediated only by the physical and chemical properties of the bonds, the substrate and the cell independent of intracellular biological processes is a current research topic. Besides experimental methods to study cellular adhesion their exist several different theoretical models to describe the stability of focal adhesion clusters. The model proposed in this work allows to understand the formation of adhesion bond clusters. It explains the emergence of a long–range bond–bond attraction that originates from the finite membrane elasticity as the driving force of cluster growth. The model extents conventional two–state models where bonds are either open or closed by introducing a rich scenario of metastable states associated with hysteretic behaviour in the bond closure/rupture dynamics.	de
dc.contributor.coReferee	Rehfeldt, Florian Dr.
dc.subject.ger	Fokalkontakt	de
dc.subject.ger	Integrine	de
dc.subject.ger	Zelladhäsion	de
dc.subject.ger	Adhäsionscluster	de
dc.subject.ger	Monte Carlo	de
dc.subject.eng	focal adhesions	de
dc.subject.eng	integrin clustering	de
dc.subject.eng	cell adhesion	de
dc.subject.eng	focal contacts	de
dc.subject.eng	modelling adhesion	de
dc.subject.eng	adhesion cluster	de
dc.subject.eng	monte carlo	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BB24-2-2
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.identifier.ppn	766211886

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