| dc.contributor.advisor | Post, Heiner PD Dr. | |
| dc.contributor.author | Schultz, Georg | |
| dc.date.accessioned | 2013-08-27T08:44:02Z | |
| dc.date.available | 2013-10-01T22:50:04Z | |
| dc.date.issued | 2013-08-27 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0001-BB35-B | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-3991 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-3991 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Koronare Mikroembolisation am Kaninchenmodell: Simvastatin vermindert die Inflammation und myokardiale Dysfunktion nach koronarer Mikroembolisation | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Coronary microembolisation in the rabbit model: Simvastatin supresses inflammation and myocardial dysfunction after coronary microembolisation | de |
| dc.contributor.referee | Pieske, Burkert Prof. Dr. | |
| dc.date.examination | 2013-09-24 | |
| dc.description.abstracteng | Background: Coronary microembolisation (CME) frequently occurs during spontaneous coronary plaque rupture and coronary angioplasty. In experimental studies, CME induces a pronounced inflammatory response that decreases contractile function of embolized myocardium for several days. Since statins exert anti-inflammatory effects, we tested whether simvastatin (Sim) would preserve left ventricular (LV) function after CME.
Methods and Results: In anaesthetized rabbits, polysterol microspheres (45 µM diameter, n=10.000-30.000) were infused into the left main coronary artery via a 3 F catheter during fluoroscopy. Animals received Sim (3 mg/kg/day p.o., n=10) or placebo (P, n=14) from 3 days before until 9 days after CME. Three animals treated with P but none treated with Sim died within 24 h after CME. Troponin T increased to a similar extent at 1 day after CME (P 3.5±1.1, Sim 3.5±1.0 ng/ml). In P, LV shortening fraction (SF, echocardiography) was decreased at day 2 after ME (32±2 vs 40±1%, p<0.05) but was preserved in Sim (40±2 vs 41±1%). SF recovered completely at 9 days after CME (P 43±2%, Sim 41±2%). At 2 days after CME, Sim also prevented LV dilatation and attenuated the decrease of LV ejection fraction. LV myocardial fibrosis was not different between P and Sim at 9 days after CME (15.3±1.5 vs 14.2±1.4 %, picrosirius red). In further animals sacrificed at 2 days after CME, Sim suppressed macrophage infiltration and tumor necrosis factor alpha expression (immunohistochemistry).
Conclusion: CME induces a transient, inflammatory phase of myocardial dysfunction that can effectively be prevented by simvastatin. These data support the immediate use of statins during acute coronary syndromes. | de |
| dc.contributor.coReferee | Danner, Bernhard C. PD Dr. | |
| dc.subject.eng | coronary microembolisation | de |
| dc.subject.eng | simvastatin | de |
| dc.subject.eng | myocardial inflammation | de |
| dc.subject.eng | myocardial dysfunction | de |
| dc.subject.eng | rabbits | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BB35-B-5 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2013-10-01 | |
| dc.identifier.ppn | 766409619 | |