Veränderungen der basal vorhandenen Menge an Interleukin-8 in oralen Keratinozyten  nach der Stimulation mit probiotischen Extrakten aus Lactobacillus rhamnosus und Lactobacillus salivarius

Veränderungen der basal vorhandenen Menge an Interleukin-8 in oralen Keratinozyten nach der Stimulation mit probiotischen Extrakten aus Lactobacillus rhamnosus und Lactobacillus salivarius

Changes in the basally existing amount of Interleukin-8 in oral keratinocytes after stimulation with probiotic extracts from Lactobacillus rhamnosus and Lactobacillus salivarius

Mirjam Mujakovic

Doctoral thesis

Date of Examination: 2013-09-11

Date of issue: 2013-09-03

Advisor: Miosge, Nicolai Prof. Dr.

Referee: Eiffert, Helmut Prof. Dr. Dr.

Referee: Mausberg, Rainer Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0001-BB47-3

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Abstract

English

The skin as barrier to the outside world protects underlying structures. Various cells of the stratified epithelium have the ability to respond to inflammation with the production of specific mediators. Inducing immune modulating effects in different type of cells, probiotics can be of healthy benefit for the host.. Interleukin-8 as a mediator of inflammation is a messenger of CXC-motif-chemokines. Il-8 is involved in the chemotactic recruit of leukocytes to inflamed tissue and therefore acts proinflammatory. After in vitro stimulation of oral keratinocytes with probiotic extracts, the basally existing amount of Il-8 changes measurably.

Keywords: Probiotics; Interleukin-8