Der Einfluss von Neuregulin-1 auf die Remyelinisierung im peripheren Nervensystem

Stassart, Ruth Martha

dc.contributor.advisor	Sereda, Michael Werner Prof. Dr.
dc.contributor.author	Stassart, Ruth Martha
dc.date.accessioned	2013-09-05T09:32:23Z
dc.date.available	2013-09-18T22:50:05Z
dc.date.issued	2013-09-05
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0001-BB5C-8
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4013
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Der Einfluss von Neuregulin-1 auf die Remyelinisierung im peripheren Nervensystem	de
dc.type	doctoralThesis	de
dc.title.translated	The role of neuregulin-1 in peripheral nervous system remyelination	de
dc.contributor.referee	Sereda, Michael Werner Prof. Dr.
dc.date.examination	2013-09-10
dc.description.abstracteng	The peripheral nervous system demonstrates an exceptional plasticity after nerve injury and Schwann cells remyelinate newly regenerated axons. However, myelin sheath thickness does not reach its original thickness and axons remain hypomyelinated after injury. During peripheral nerve development, the transmembrane growth factor neuregulin-1 type III is expressed on the axonal surface and regulates Schwann cell development as well as myelin sheath thickness. After peripheral nerve injury, Wallerian degeneration is induced and Schwann cells remain without axons and, hence, axonal neuregulin-1 type III stimulation. We demonstrate that during this time period, denervated Schwann cells strongly induce the expression of the paracrine type I isoform of neuregulin-1 which is barely detectable in non-injured nerves. Mutant mice with a specific deletion of the neuregulin-1 gene in Schwann cells are fully myelinated during development, but exhibit impaired remyelination after experimental peripheral nerve injury. We suggest a model in which loss of axonal contact triggers denervated Schwann cells to transiently express neuregulin-1 as an endogeneous signal that promotes Schwann cell redifferentiation and remyelination.	de
dc.contributor.coReferee	Simons, Mikael Prof. Dr.
dc.contributor.thirdReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	Neuregulin-1	de
dc.subject.ger	Peripheres Nervensystem	de
dc.subject.ger	Remyelinisierung	de
dc.subject.ger	Schwannzelle	de
dc.subject.eng	neuregulin-1	de
dc.subject.eng	peripheral nervous system	de
dc.subject.eng	remyelination	de
dc.subject.eng	Schwann cell	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BB5C-8-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin	de
dc.description.embargoed	2013-09-18
dc.identifier.ppn	767427386

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Human- und Zahnmedizin [2872]

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