• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Zentren & Graduiertenschulen
  • GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
  • Item View
  •   Home
  • Zentren & Graduiertenschulen
  • GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Genetics of Drosophila hearing

by David Piepenbrock
Doctoral thesis
Date of Examination:2013-09-27
Date of issue:2013-10-04
Advisor:Prof. Dr. Martin Göpfert
Referee:Prof. Dr. Tobias Moser
Referee:Prof. Dr. André Fiala
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-4075

 

 

Files in this item

Name:Dissertation_David_Piepenbrock_Genetics_of_D...pdf
Size:20.3Mb
Format:PDF
ViewOpen

The following license files are associated with this item:


Abstract

English

By probing Johnston’s organ function in mutant fly strains, mutations in forty-four genes that affect Drosophila hearing have been identified. This result increases the list of genes that are known for audition by 180 % (forty-four new versus twenty-four old). I defined several auditory categories based on the change in auditory performance: nine mutations severely impaired Johnston’s organ function, twenty-nine moderately, and six are hypersensitive. This list of hearing genes includes motor proteins, ion channels, and genes that are involved in response to light. With this surprising result, I screened for contributions of genes of the phototransduction cascade to Drosophila hearing, and found that key proteins of the cascade functionally contribute to hearing. Probing correlates of transducer gating revealed that rhodopsins affect mechano-electrical transduction and antibody staining indicates that rhodopsins are expression in Johnston’s organ neurons. In addition, my analysis of flies with duplicated NOMPC ankyrin residues foster the hypothesis that ankyrins may act as gating springs that convey mechanical force to transduction channels.
Keywords: sensory neurobiology; sensory neuroscience; Drosophila melanogaster; hearing; mechano-electrical transduction; screen; atonal; deafness; hearing impairment; blueprint of Drosophila hearing
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]