Genetics of Drosophila hearing

Piepenbrock, David

dc.contributor.advisor	Göpfert, Martin Prof. Dr.
dc.contributor.author	Piepenbrock, David
dc.date.accessioned	2013-10-04T08:33:37Z
dc.date.available	2013-10-04T08:33:37Z
dc.date.issued	2013-10-04
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0001-BBC2-F
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4075
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	570	de
dc.title	Genetics of Drosophila hearing	de
dc.type	doctoralThesis	de
dc.contributor.referee	Moser, Tobias Prof. Dr.
dc.date.examination	2013-09-27
dc.description.abstracteng	By probing Johnston’s organ function in mutant fly strains, mutations in forty-four genes that affect Drosophila hearing have been identified. This result increases the list of genes that are known for audition by 180 % (forty-four new versus twenty-four old). I defined several auditory categories based on the change in auditory performance: nine mutations severely impaired Johnston’s organ function, twenty-nine moderately, and six are hypersensitive. This list of hearing genes includes motor proteins, ion channels, and genes that are involved in response to light. With this surprising result, I screened for contributions of genes of the phototransduction cascade to Drosophila hearing, and found that key proteins of the cascade functionally contribute to hearing. Probing correlates of transducer gating revealed that rhodopsins affect mechano-electrical transduction and antibody staining indicates that rhodopsins are expression in Johnston’s organ neurons. In addition, my analysis of flies with duplicated NOMPC ankyrin residues foster the hypothesis that ankyrins may act as gating springs that convey mechanical force to transduction channels.	de
dc.contributor.coReferee	Fiala, André Prof. Dr.
dc.subject.eng	sensory neurobiology	de
dc.subject.eng	sensory neuroscience	de
dc.subject.eng	Drosophila melanogaster	de
dc.subject.eng	hearing	de
dc.subject.eng	mechano-electrical transduction	de
dc.subject.eng	screen	de
dc.subject.eng	atonal	de
dc.subject.eng	deafness	de
dc.subject.eng	hearing impairment	de
dc.subject.eng	blueprint of Drosophila hearing	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BBC2-F-5
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	769136672

Dateien

Name:Dissertation_David_Piepenbrock_Genetics_of_Drosophila_hearing.pdf

Größe:20.37Mb

Format:PDF

Öffnen

Name:: Dissertation_David_Piepenbrock ...
Größe:: 20.37Mb
Format:: PDF

Öffnen

Das Dokument erscheint in:

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1112]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

Zur Kurzanzeige