dc.contributor.advisor | Laskawi, Rainer Prof. Dr. | |
dc.contributor.author | Niemczewska-Dreher, Anna Maria | |
dc.date.accessioned | 2013-10-30T13:19:17Z | |
dc.date.available | 2013-12-02T23:50:05Z | |
dc.date.issued | 2013-10-30 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0001-BC12-2 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4123 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Langzeitbeobachtungen zur Injektionsdynamik der Botulinum-Toxin-Therapie bei Patienten mit verschiedenen fazialen Dyskinesien | de |
dc.type | doctoralThesis | de |
dc.title.translated | Long term observations in the dynamic of botulinum toxin treatment in patients with facial movement disorders | de |
dc.contributor.referee | Laskawi, Rainer Prof. Dr. | |
dc.date.examination | 2013-11-25 | |
dc.description.abstracteng | Abstract
Background: Rare information exists about the long term development of patients with
blepharospasm, hemifacial spasm and synkinesis following defective healing of the facial nerve. This
retrospective analysis deals with the course of different parameters of injection over the time.
Methods: In this study we analysed the development of long-term botulinum toxin treatments of
patients with blepharospasm, hemifacial spasm and synkinesis. 80 patients (female 59, male 21,
mean age 68 years, range 41-93 years, n=30 blepharospasm, n=31 hemifacial spasm, n=19
synkinesis) of the clinic for head and neck movement disorders, department of ENT of the Georg-
August-University Goettingen, Germany, who had at least 10 consultations for BTA-injections, were
included in the retrospective study. The development for each entity in total dosage, increase in the
number of injection points and change in dosages for each point were evaluated.
Results: The over-all dosage in all three clinical pictures and for each single disease itself increased
continuously over the time. The amount of injection points increased in the treatment of hemifacial
spasm and synkinesis. The dosage per point increased most in blepharospasm, but was distinctly
lower in patients with hemifacial spasm and synkinesis (lowst level). The increase in dosage in
blepharospasm is therefore, in contrast to hemifacial spasm and synkinesis, mostly caused by an
increase in dosage per point in relatively constant injection points.
Conclusion: These new aspects of the dynamic in the treatment with botulinum toxin enable the
physician to understand better the dynamic of these diseases, to optimize treatment protocols and to
improve counseling. | de |
dc.contributor.coReferee | Liebetanz, David Prof. Dr. | |
dc.subject.ger | Blepharospasmus | de |
dc.subject.ger | Spasmus hemifacialis | de |
dc.subject.ger | Synkinesien | de |
dc.subject.ger | vergleichende Langzeitbeobachtungen | de |
dc.subject.ger | Botulinumtoxin | de |
dc.subject.eng | Blepharospasm | de |
dc.subject.eng | Hemifacial Spasm | de |
dc.subject.eng | Facial Synkinesis | de |
dc.subject.eng | Longterm Results | de |
dc.subject.eng | Botulinum Toxin | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BC12-2-6 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Oto-Rhino-Laryngologie (PPN619876220) | de |
dc.description.embargoed | 2013-12-02 | |
dc.identifier.ppn | 77069733X | |