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dc.contributor.advisor Brück, Wolfgang Prof. Dr.
dc.contributor.author Vondran, Andrea Christina
dc.date.accessioned 2013-11-01T10:06:25Z
dc.date.available 2013-12-03T23:50:06Z
dc.date.issued 2013-11-01
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0001-BC1C-E
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc 610 de
dc.title Quantitative Untersuchung der Oligodendrozytendichte im Kortex von Callithrix-jacchus Marmosetten mit Experimenteller Autoimmuner Enzephalomyelitis de
dc.type doctoralThesis de
dc.title.translated Quantitative analysis of oligodendroglial densitiy in the cortex of callithrix-jacchus marmosets with experimental autoimmune encephalomyelitis de
dc.contributor.referee Brück, Wolfgang Prof. Dr.
dc.date.examination 2013-11-26
dc.description.abstracteng Histopathological studies of Multiple sclerosis (MS) are usually limited by the fact that autopsy tissue is usually from patients in the chronic stage of the disease. Thus far there are only few results on the pathology of oligodendrocytes in early cortical lesions in patients with MS. The recent findings on the pathogenesis of MS in the early stages of the disease are essentially based on the animal model of experimental autoimmune-mediated encephalomyleitis (EAE). The distribution pattern of EAE in the marmoset monkey is similar to the MS. In both diseases cortical lesions can be detected. The aim of this study was to investigate the pathology of oligodendrocytes in early cortical lesions in the EAE animal model. The densitiy of p25- and NogoA-positive oligodendrocytes was determined in the deep cortical layers in demyelinated and normal-appearing cortex. Furthermore, the density of macrophages, CD3-positive T-cells, CD20-positive B-cells and IgG-positive plasmacells in lesions was determined. The density of oligodendrocytes was significantly reduced in lesions compared with normal appearing cortex, resulting with a significantly higher proportion of p25-positive oligodendrocytes within the lesions compared to NogoA-positive oligodendrocytes. Quantitative analysis of inflammatory cells in the lesions revealed a majority of macrophages followed by T-cells, B-cells and few plasmacells. The results of this work show that oligodendrocyte loss is already common in demyelinated cortical lesions in marmosets with early stage of EAE. Since EAE in the marmosets is the animal model with the highest similarity to the human MS, these results suggest that also in early cortical MS lesions oligodendrocytes occur damage by a T-cell mediated antibody/complement reaction. de
dc.contributor.coReferee Flügel, Alexander Prof. Dr.
dc.contributor.thirdReferee Oppermann, Martin Prof. Dr.
dc.subject.eng Multiple sclerosis de
dc.subject.eng oligodendrocytes de
dc.subject.eng cortical lesions de
dc.subject.eng Experimental autoimmune-mediated encephalomyelitis de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0001-BC1C-E-7
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.subject.gokfull Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674) de
dc.description.embargoed 2013-12-03
dc.identifier.ppn 770773699

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