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Funktionell- hirnbildgebende Untersuchung zu endophänotypischen Markern bei erstgradigen Angehörigen bipolarer Patienten

dc.contributor.advisorGruber, Oliver Prof. Dr.
dc.contributor.authorJakob, Kathrin
dc.titleFunktionell- hirnbildgebende Untersuchung zu endophänotypischen Markern bei erstgradigen Angehörigen bipolarer Patientende
dc.title.translatedFunctional brain-imaging study for endo phenotypic markers in first-degree relatives of bipolar patientsde
dc.contributor.refereeDechent, Peter PD Dr.
dc.description.abstractengBackground: Bipolar disorder is marked by multifactorial etiology. As there is no evidence for a uniform etiology the search for neurobiological correlates, so called endophenotypes, are an important part of the research approach. Endophenotypes, which seem to have a close relationship to the genome, are important to investigating pathogenetic factors of disease. The use of functional magnetic resonance imaging (fMRI) to explore neural activity, particularly impairments in working memory and reward system, in samples of bipolar disorder patients and their unaffected first-degree relatives may present potential neurobiological endophenotypes for this disorder. Aim: The aim of this study (with the help of functional-brain imaging investigations) was to find more endophenotypical markers in working memory and reward system with the assistance of healthy, unaffected, first degree relatives of people with bipolar disorder. Method: 18 unaffected first degree relatives and 18 healthy controls performed a modified “Sternberg-paradigm” to investigate human verbal and visospatial working memory. In addition to this, the reward system, selective attention and task switching (with oddballs and incongruence) were also tested. Results: Hyper activation of the left praecentral and right middle frontal gyrus was shown in the relatives during articulatory rehearsal. When testing the visospatial working memory, higher activations were shown in the area of the ventral striatum/anterior thalamus and bilateral superior parietal lobules. During the “Desire-reason-Dilemma”-paradigm, both groups (relatives and controls) presented activations in the same brain areas (mesolimbic dopamine system) found in preliminary studies. In relation to the system of background monitoring and attention control no consistent findings could be shown. Conclusion: Brain activations during working memory tasks and reward system processes differentiated unaffected first degree relatives from healthy controls and marked potential candidates of endophenotypes. In the relatives more activation was shown in the left praecentral and right middle frontal gyrus during verbal working memory processes. More activation was also found in the ventral striatum/anterior thalamus and bilateral superior parietal lobuli during visual-spatial working memory process. The investigation of the reward system showed a hypo activation of the relatives in the area of the right thalamus, another potential endophenotype
dc.contributor.coRefereeOppermann, Martin Prof. Dr.
dc.subject.gerBipolare Störungde
dc.subject.gervisuelles und verbales Arbeitsgedächtnisde
dc.subject.gerAngehörige ersten Gradesde
dc.subject.gerSternberg Paradigmade
dc.subject.gerOddball und Inkongruenz Paradigmade
dc.subject.engbipolar disorderde
dc.subject.engworking memoryde
dc.subject.engreward systemde
dc.subject.engunaffected first-degree relativesde
dc.subject.engfunctional-brain imagingde
dc.subject.engverbal and visospatial working memoryde
dc.subject.engoddball and incongruencede
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de

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