The main focus of this work was the development of new methodologies for the efficient and step-economical synthesis of biaryls cores by direct arylation through direct C–H bond cleavage. In this aim, the first ruthenium-catalyzed direct arylation of arenes bearing a removable directing group was achieved. Furthermore, a step-economical synthesis to the antihypertensive Valsartan was successful with ruthenium as a catalyst. Afterwards, we developed a new bidentate directing group for the efficient ruthenium-catalyzed direct arylation of amides.
Keywords: catalysis; C–H bond functionalization; ruthenium; sustainable chemistry; biaryls; Valsartan
