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Ruthenium-Catalyzed Synthesis of Biaryls through C–H Bond Functionalizations

by Emelyne Diers
Doctoral thesis
Date of Examination:2013-10-14
Date of issue:2013-11-15
Advisor:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Ulf Diederichsen
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-4166

 

 

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Abstract

English

The main focus of this work was the development of new methodologies for the efficient and step-economical synthesis of biaryls cores by direct arylation through direct C–H bond cleavage. In this aim, the first ruthenium-catalyzed direct arylation of arenes bearing a removable directing group was achieved. Furthermore, a step-economical synthesis to the antihypertensive Valsartan was successful with ruthenium as a catalyst. Afterwards, we developed a new bidentate directing group for the efficient ruthenium-catalyzed direct arylation of amides.
Keywords: catalysis; C–H bond functionalization; ruthenium; sustainable chemistry; biaryls; Valsartan
 

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