Physiologische und morphologische Charakterisierung des dopaminergen Systems in der olfaktorischen Peripherie von Xenopus-laevis-Larven

Physiological and morphological Characterisation of the dopaminergig System in the olfactory periphery of Xenopus-laevis larvae

by Valentin Schriever
Doctoral thesis
Date of Examination:2012-11-20
Date of issue:2013-11-18
Advisor:Prof. Dr. Dr. Detlev Schild
Referee:Prof. Dr. Detlev Schild
Referee:Prof. Dr. Martin Sommer
Persistent Address: http://dx.doi.org/10.53846/goediss-3883

 

 

Files in this item

Name:utf-8''Schriever_dissertation2X.pdf
Size:2.05Mb
Format:PDF
Description:Dissertation

The following license files are associated with this item:

Abstract

English

It has been shown in many studies, that dopamine plays an important role in the olfactory system. In the current study I was examining the physiological and morphological characteristics of the dopaminergic system in the olfactory periphery of Xenopus laevis larva. Measurements were made by means of confocal calcium imaging and immunohistochemistry. The results show, that dopamine modulates the odor-induced responses of olfactory receptor neurons via the dopamine D-2 receptor. While the olfactory ensheathing cells were identified as a dopamine source in the olfactory periphery, the axons of the olfactory receptor neurons expressed dopamine D-2 receptors. In addition to the dopaminergic modulation the influence of antipsychotic drugs on the odor-induced responses of olfactory receptor neurons could be observed. This current work shows a physiological effect on the olfactory receptor neurons as well as the morphological distribution of dopamine receptors in the olfactory periphery. It underlines the importance of the dopaminergic system in the olfactory periphery. 
Keywords: dopamine, olfaction, Xenopus
Schlagwörter: Dopamin, Riechen, Xenopus
 
Statistik