New and Bioactive Secondary Metabolites from Ma-rine and Terrestrial Bacteria: Ramthacin A, B, C, and Polyene Macrolides from Genetically Modified Bacteria

New and Bioactive Secondary Metabolites from Ma-rine and Terrestrial Bacteria: Ramthacin A, B, C, and Polyene Macrolides from Genetically Modified Bacteria

Ibrahim Al-Refa Mahmoud Hussien

Doctoral thesis

Date of Examination: 2008-10-30

Date of issue: 2009-01-09

Advisor: Laatsch, Hartmut Prof. Dr.

Referee: Zeeck, Axel Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0006-ACBA-1

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Abstract

English

Natural products have provided the major sources of chemical diversity for phar-maceutical discoveries for many decades. For clinical application to treat human dis-eases in almost all therapeutic areas, many natural products and synthetically modi-fied natural products have been successfully used. In the search for novel and bioac-tive molecules for discovery of new drugs, marine-derived natural resources are be-coming an important research area.

Keywords: Ma-rine Bacteria Terrestrial Bacteria; Ramthacin A; B; C; Polyene Macrolides