Synthesis of Potentially Biologically Active Cyclopropane- and Spirocyclopropane-annelated Oligoazaheterocycles

Gensini, Martina

dc.contributor.advisor	Meijere, Armin de Prof. Dr.	de
dc.contributor.author	Gensini, Martina	de
dc.date.accessioned	2004-11-23T15:08:27Z	de
dc.date.accessioned	2013-01-18T10:35:08Z	de
dc.date.available	2013-01-30T23:51:23Z	de
dc.date.issued	2004-11-23	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0006-AD46-E	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-2102
dc.description.abstract	In dieser Arbeit die Synthese von neuen cyclopropane- and spirocyclopropane-anellierten Heterocyclen wurde geschrieben. Die Intramoleculare Titan-vermittelte Cyclopropanierung von 2-allylamino-N,N-dialkylpropionamide wurde untersucht in der Synthese von 1-Amino-3-azabicyclo[3.1.0]hexane bzw. 1-Amino-3-azabicyclo[4.1.0]heptane Produkte. Tri- bzw. tetracyclen mit ring-anellierte Azabicyclo[3.1.0]hexane Systeme wurden synthetisiert von Indole, Indoline, Pyrrole and Proline N-allyl-Producte durch Intramoleculare Titan-vermittelte Cyclopropanierung.Im zweiten Teil der Arbeit die 1,3-dipolare Cycloadditione von verschiedene Nitronen mit Cyclopropylidenespiropentane and 7-cyclopropylidenedispiro[2.0.2.1]heptane und danach thermische Umlagerung von isoxazolidinen wurde untersucht. Diese Prozessen führten zu neuen Tetrahydropyridonederivaten mit spirocyclopropane-anellierte Ringe.	de
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://webdoc.sub.gwdg.de/diss/copyr_diss.html	de
dc.title	Synthesis of Potentially Biologically Active Cyclopropane- and Spirocyclopropane-annelated Oligoazaheterocycles	de
dc.type	doctoralThesis	de
dc.title.translated	Synthese von potentiellen biologischen aktiven cyclopropane- und spirocyclopropane-anellierten Oligoheterocyclen	de
dc.contributor.referee	Meijere, Armin de Prof. Dr.	de
dc.date.examination	2003-01-30	de
dc.subject.dnb	540 Chemie	de
dc.description.abstracteng	In this work the synthesis of new cyclopropane- and spirocyclopropane-annelated heterocyclic compounds containing nitrogen has been reported. The Ti-mediated intramolecular reductive cyclopropanations of 2-allylamino-N,N-dialkylpropionamides were investigated towards the synthesis of 1-amino-3-azabicyclo[3.1.0]hexane and 1-amino-3-azabicyclo[4.1.0]heptane derivatives. Tri- and tetracyclic derivatives containing ring-annelated azabicyclo[3.1.0]hexane systems were prepared from indole, indoline, pyrrole and proline N-allyl derivatives by Ti-mediated intramolecular reductive cyclopropanations.In the second part of this thesis the 1,3-dipolar cycloaddition of various nitrones to the highly strained cyclopropylidenespiropentane and 7-cyclopropylidenedispiro[2.0.2.1]heptane and subsequent thermal rearrangement of the intermediate isoxazolidines was investigated. Such processes led to the formation of new tetrahydropyridone derivatives with up to three spirocyclopropane-annelated rings.	de
dc.contributor.coReferee	Diederichsen, Ulf Prof. Dr.	de
dc.subject.topic	Mathematics and Computer Science	de
dc.subject.ger	Metallkomplexe	de
dc.subject.ger	Katalyse	de
dc.subject.ger	Titan	de
dc.subject.ger	Palladium	de
dc.subject.ger	Cycloadditionen	de
dc.subject.eng	metal complexes	de
dc.subject.eng	catalysis	de
dc.subject.eng	titanium	de
dc.subject.eng	palladium	de
dc.subject.eng	cycloadditions	de
dc.subject.bk	35.52	de
dc.subject.bk	35.59	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-218-6	de
dc.identifier.purl	webdoc-218	de
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	SU 000: Organische Chemie	de
dc.subject.gokfull	SUD 000: Reaktionen in der organischen Chemie	de
dc.subject.gokfull	SUH 900: Metallorganische Verbindungen {Organische Chemie}	de
dc.subject.gokfull	SUN 000: Cyclische Verbindungen {Organische Chemie}	de
dc.identifier.ppn	478788711	de

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