• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Naturwissenschaften, Mathematik und Informatik
  • Fakultät für Chemie (inkl. GAUSS)
  • Item View
  •   Home
  • Naturwissenschaften, Mathematik und Informatik
  • Fakultät für Chemie (inkl. GAUSS)
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Bioactive Secondary Metabolites from Marine and Terrestrial Bacteria: Isoquinolinequinones, Bacterial Compounds with a Novel Pharmacophor

Bioaktive Sekundärmetabolite aus marinen und terrestrischen Bakterien; Isochinolin-Chinone, bakterielle Verbindungen mit einem neuartigen Pharmakophor

by Mohamed Attia Shaaban Mahmoud
Doctoral thesis
Date of Examination:2004-11-02
Date of issue:2005-01-17
Advisor:Prof. Dr. Hartmut Laatsch
Referee:Prof. Dr. Helmut Lackner
Referee:Prof. Dr. Axel Zeeck
Referee:PD Dr. Karen Hirsch-Ernst
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-2134

 

 

Files in this item

Name:mahmoud.pdf
Size:2.50Mb
Format:PDF
Description:Dissertation
ViewOpen

The following license files are associated with this item:


Abstract

English

After a chemical and biological pre-screening of bacterial extracts, 17 Streptomycetes (including eleven terrestrial and six marine-derived strains) and ten North Sea bacteria (including five Roseobacter strains) were studied in detail. From the North Sea strains, 47 compounds were obtained, from which eleven are new secondary metabolites from bacteria. The eleven terrestrial Streptomycetes were found to produce 45 compounds, out of which ten natural products are reported here for the first time. From the marine Streptomycetes 25 compounds were isolated, five of which were new natural products. Altogether, 118 metabolites were isolated, including, 6 macrolides, 1 peptide, 13 quinones, 3 polyenes, and 2 isoquinolinequinones. Their structures were elucidated using spectroscopic methods, including HPLC-MS, MALDI-TOF, and NMR experiments. Biological activities were tested against bacteria, fungi, algae, saline shrimps, and nematodes.
Keywords: Antibiotica; Terrestrial and marine bacteria; Isoquinolinquinones; Secondary Metabolites

Other Languages

Nach einem chemischen und biologischen Vorscreening von Bakterienextrakten wurden 17 Streptomyceten (davon elf terrestrische und sechs marine Stämme) und zehn Nordsee-Bakterien (davon fünf Roseobacter-Stämme) genauer untersucht. Aus den Nordsee-Stämmen wurden 47 Verbindungen isoliert, von denen elf das erste Mal aus Bakterien isoliert wurden. Die elf terrestrischen Streptomyceten produzierten 45 Verbindungen, von denen zehn hier das erste Mal beschrieben werden. Aus den marinen Streptomyceten wurden 25 Verbindungen isoliert, von denen fünf neue Naturstoffe sind. Insgesamt wurden 118 Stoffe isoliert, darunter 6 Makrolide, 1 Peptid, 13 Chinone, 3 Polyene und 2 Isochinolin-Chinone. Ihre Strukturen wurden mit Hilfe spektroskopischer Methoden wie HPLC-MS, MALDI-TOF und NMR-Experimenten aufgeklärt. Zusätzlich wurde die biologische Aktivität gegen Bakterien, Pilze, Algen, Salinenkrebse und Nematoden untersucht.
Schlagwörter: Antibiotika; terrestrische und marine Bakterien; Isochinolin-Chinone; Sekundärstoffe
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]