Zur Kurzanzeige

Hemisphere and region - specific effects of chronic stress in the rat prefrontal cortex

dc.contributor.advisorFuchs, Eberhard Prof. Dr.de
dc.contributor.authorPerez-Cruz, Claudiade
dc.date.accessioned2007-05-03T06:48:43Zde
dc.date.accessioned2013-01-18T14:28:50Zde
dc.date.available2013-01-30T23:51:09Zde
dc.date.issued2007-05-03de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0006-B36A-2de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3301
dc.format.mimetypeapplication/pdfde
dc.language.isoengde
dc.rights.urihttp://webdoc.sub.gwdg.de/diss/copyr_diss.htmlde
dc.titleHemisphere and region - specific effects of chronic stress in the rat prefrontal cortexde
dc.typedoctoralThesisde
dc.title.translatedHemisphärische und Region - spezifische Effekte von chronischen Stress im präfrontalen Kortex der Rattede
dc.contributor.refereeKirchheim, Reiner Prof. Dr.de
dc.date.examination2007-04-18de
dc.subject.dnb570 Biowissenschaftende
dc.subject.dnbBiologiede
dc.description.abstractengThis thesis demonstrated that pyramidal neurons of the prelimbic and infralimbic area of the rat prefrontal cortex had an intrinsic morphological asymmetry in that pyramidal neurons in the right hemisphere presented longer apical dendrites compared to the left. Stress induced-morphological alterations in pyramidal neurons were regionand hemispheric dependent, resulting in a final loss of hemisphere lateralization. Stressinduced retraction of apical dendrites in right infralimbic and prelimbic areas; however in anterior cingulated cortex apical dendrites were retracted in the left hemisphere. In addition, stress causes retraction of basal dendrites proximal to soma in the prelimbic area with concomitant reduction in spine density. Furthermore, the right prelimbic area showed reductions in apical dendrites after intraperitoneal injections of vehicle, demonstrating that this sub-area of the prefrontal cortex is highly sensitive to stress. The effects of diurnal cycle and stress on spine densities in basal dendrites were also investigated. Surprisingly, control rats presented a diurnal variation in the number of spines in the left hemisphere. Chronic stress shifted this circadian variation to the right hemisphere. These alterations were selectively localized in proximal basal dendrites. The effectiveness of an antidepressant, tianeptine, to abolish the dendritic remodeling caused by stress was evaluated. The drug did not restore the morphological changes induced by stress; however, physiological alterations induced by stress were successfully blocked by tianeptine. It is hypothesized that these morphological remodeling of pyramidal neurons in the prefrontal cortex may have an important regulatory function in stress responses and might be part of an adaptive strategy to cope with stressful situations. This study offers important information to the field of stress research, as it is the first description of a region- and hemisphere- specific effects of stress in the rat prefrontal cortex.de
dc.contributor.coRefereeStoykova, Anastassia PD Dr.de
dc.contributor.thirdRefereeHeinrich, Ralf Prof. Dr.de
dc.subject.topicMolecular Biology & Neurosciences Programde
dc.subject.gerPräfrontaler Kortex Stress Pyramiden Neuronede
dc.subject.engPrefrontal cortex stress pyramidal neuronsde
dc.subject.bk42de
dc.identifier.urnurn:nbn:de:gbv:7-webdoc-1463-0de
dc.identifier.purlwebdoc-1463de
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften und molekulare Biowissenschaften (GGNB)de
dc.subject.gokfullWde
dc.identifier.ppn57921138Xde


Dateien

Thumbnail

Das Dokument erscheint in:

Zur Kurzanzeige