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dc.contributor.advisor Brenig, Bertram Prof. Dr. Dr. de
dc.contributor.author Spittau, Gabriele de
dc.date.accessioned 2012-11-15T15:10:20Z de
dc.date.accessioned 2013-01-18T10:19:10Z de
dc.date.available 2013-01-30T23:51:20Z de
dc.date.issued 2012-11-15 de
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-000D-EF49-C de
dc.format.mimetype application/pdf de
dc.language.iso ger de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ de
dc.title Untersuchungen zur Rolle von Klf10 und Klf11 als Mediatoren von NGF- und TGF-β-vermittelten Effekten in Zellen neuraler Herkunft de
dc.type doctoralThesis de
dc.title.translated Investigations into the role of Klf10 and Klf11 as mediators of NGF- and TGF-beta-mediated effects in cells of neural origin de
dc.contributor.referee Brenig, Bertram Prof. Dr. Dr. de
dc.date.examination 2011-11-17 de
dc.subject.dnb 000 Allgemeines de
dc.subject.dnb Wissenschaft de
dc.subject.gok WKF 300 de
dc.description.abstracteng The TGF-β1/Klf-family of transcription factors. They play important roles in development and maintenance of various tissues and cell types. The publications consolidated in this thesis describe, that Klf11 mimics TGF-β effects by inducing apoptotsis accompanied by activation of cysteine-dependent aspartate-specific protease 3 (Caspase-3). Further the thesis demonstrates that Klf11 represses the expression of the inhibitory Sma and Mad related protein 7 (Smad7) and disrupts the negative-feedback loop of the TGF-β signaling pathway. Loss of the N-terminal repression domains of Klf11 abrogates its proapoptotic nature and the repression of Smad7. In conclusion, the evidence was given that the transcription factor Klf11 is a downstream mediator of TGF-β-induced apoptosis and a potent modulator of the TGF-β signaling pathway in the oligodendroglial cell line Oli-neu. In a second part of this thesis it has been shown by using semiquantitative PCR and immunoblotting, that nerve growth factor (NGF), a member of the neurotrophin family, regulates the expression of Klf10 in the pheochromocytoma cell line PC12 in a tropomyosin related kinase A- (TrkA) dependent manner. Moreover, the thesis provides evidence for the existence of NGF-responsive elements in the 5 de
dc.contributor.coReferee Knorr, Christoph Prof. Dr. de
dc.contributor.thirdReferee Krieglstein, Kerstin Prof. Dr. de
dc.subject.topic Agricultural Sciences de
dc.subject.ger Klf10 de
dc.subject.ger Klf11 de
dc.subject.ger Sp1-/Krüppelähnliche Transkriptionsfaktoren de
dc.subject.ger Apoptose de
dc.subject.ger Zellzyklusarrest de
dc.subject.ger TGF-β de
dc.subject.ger NGF de
dc.subject.ger Oli-neu-Zellen de
dc.subject.ger PC12-Zellen de
dc.subject.eng Klf10 de
dc.subject.eng KLF11 de
dc.subject.eng Sp1-/Krüppelähnliche transcription factors de
dc.subject.eng apoptosis de
dc.subject.eng cell cycle arrest de
dc.subject.eng TGF-β de
dc.subject.eng NGF de
dc.subject.eng Oli-neu-cells de
dc.subject.eng PC12-cells de
dc.subject.bk ??? de
dc.identifier.urn urn:nbn:de:gbv:7-webdoc-3793-8 de
dc.identifier.purl webdoc-3793 de
dc.affiliation.institute Fakultät für Agrarwissenschaften de
dc.identifier.ppn 733998909 de

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