Browsing Molekulare Medizin by Issue Date
Now showing items 1-20 of 263
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Impact of the Polymerization Method on the Biocompatibility of Denture Base Resins in a 3D Tissue Engineered Human Oral Mucosa Model
(2025-04-22)Poly(methyl methacrylate) (PMMA) is widely used in dentistry to fabricate removable dentures. As these materials come into direct contact with the oral mucosa, biocompatibility is essential to prevent adverse reactions ... -
The Role of Clonal Evolution and Anti- Apoptotic Dependencies in Cancer Progression and Therapy Resistance: Implications for Personalized Medicine
(2025-04-10)Cancer is characterized by significant heterogeneity, both across and within individual tumors, posing challenges for treatment. This thesis investigates clonal evolution (CE) and its association with apoptotic mechanisms ... -
The Functional Role of the Membrane Bending Ability of the Yeast PROPPINs
(2025-04-04)The meticulously regulated mechanism, which overseas processes of cellular breakdown and recycling, is called macroautophagy. It has been preserved from yeast to more advanced eukaryotic organisms. As a response to various ... -
Mechanisms of T-cell mediated inflammatory neurodegeneration
(2025-04-04)Multiple sclerosis (MS) is a T-cell mediated, chronic, demyelinating disease of the central nervous system (CNS). Neurodegeneration and axonal loss are associated with increased disability and disease progression. ... -
Antibody-mediated recognition of central nervous system antigen as therapeutic target
(2025-04-04)The discovery of autoantibodies directed against myelin oligodendrocyte glycoprotein (MOG) in a proportion of patients diagnosed with multiple sclerosis (MS) led to the definition of MOG antibody-associated disease (MOGAD) ... -
Evaluation and Targeting of the Metabolic Signature of Human Pancreatic Ductal Adenocarcinoma Subtypes
(2025-03-13)Pancreatic ductal adenocarcinoma (PDAC) presents significant therapeutic challenges due to its pronounced tumor heterogeneity and complex metabolic reprogramming within the tumor microenvironment. In this study, advanced ... -
T cell-mediated ocular autoimmunity
(2025-03-07)Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system (CNS), leading to inflammatory lesions in the brain and spinal cord. The autoimmune process can affect both the gray and ... -
Understanding Early Events of B Cell Antigen Receptor Activation: Effects of Antigen and Receptor Valency
(2025-03-07)Abstract Each B cell is equipped with B cell antigen receptors (BCRs) of a unique specificity. These BCRs are crucial in many events including B cell development, activation and differentiation. There is still an ongoing ... -
Characterisation of colorectal cancer by means of imaging to allocate patients to best treatment options
(2025-01-23)Colorectal cancer (CRC) is currently the second deadliest cancer in the world. Apart from the known prognostic factors, the role of tumour microenvironment (TME), in particular the extracellular matrix (ECM) has gained ... -
Long-term Replacement of Endogenous Microglia in Mice
(2024-12-19)Microglia are the resident immune cells of the central nervous system (CNS). They play pivotal roles in the development and homeostasis of the CNS and have been implicated in neurodegenerative disorders, such as Alzheimer´s ... -
Dissecting the Atg21 organization at the growing phagophore and the evolutionary conservation of Nvj1 among yeasts
(2024-12-09)The first project of this thesis deals with the spatial and temporal regulation of Atg21 at growing phagophores. Macroautophagy is a highly conserved process involved in the degradation and recycling of cellular material ... -
Role of the cellular prion protein in the cellular internalization and the Tau-mediated toxicity
(2024-11-15)Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of Tau within the brain, leading to neuronal dysfunction and death. These diseases are classified into 3R tauopathies, 4R ... -
Obesity and Ageing: accelerators of cognitive decline in melanocortin 4 receptor-deficient mice
(2024-10-14)Genetic or lifestyle-related obesity ails almost one billion people worldwide. Obesity is an accumulation of fat, while, ageing is an ongoing process of accumulation of harmful molecular alterations. Obesity and ageing, ... -
Regulation of the MDM4 oncogene by the ribosomal protein L22 through alternative mRNA splicing
(2024-09-27)p53 is the most frequently mutated tumor suppressor in human cancer. By acting as a transcription factor for its target genes, it causes downstream effects such as cell cycle arrest or apoptosis. To avoid excessive p53 ... -
Subcellular compartmentalization of signal elements and their re-distribution in resting and activated B cells
(2024-09-19)BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process ... -
Exploring new treatment strategies for mature T-cell neoplasms based on genetic alterations
(2024-09-10)Mature T-cell leukemias and lymphomas (mTCL) comprise a heterogeneous group of lymphoid malignancies that are generally associated with poor prognosis, low response to current standard therapy regimes and high relapse ... -
Pre-clinical assessment of the therapeutic efficacy of a nanovaccine in a mouse model of pancreatic cancer
(2024-08-09)Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases with increasing incidence in developed countries. Due to the late diagnosis of PDAC, available treatments do not significantly improve patient survival. ... -
Misp53 mutation-specific oncogenic transcription factor complexes in PDAC progression
(2024-07-02)Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second-leading cause of cancer related death by 2040 with a 5-year survival rate of only 11%. PDAC aggressiveness is attributed to its high heterogeneity ... -
3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
Functional and structural analysis approaches for translational lung disease research.
(2024-06-13)Respiratory ailments continue to pose a formidable challenge to public health. The respiratory system is a delicate interplay of muscle contraction, pressure gradients and a large surface area with thin diffusion barriers ...