Browsing Molekulare Medizin by Referee "Meyer, Thomas Prof. Dr."
Now showing items 21-28 of 28
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The histone methyltransferase DOT1L is required for DNA damage recognition and repair
(2017-02-02)New effective combinational therapeutic strategies are an alternative choice for a successful translational study. Disruptor of telomeric silencing 1-like (DOT1L) is a histone 3 lysine 79 (H3K79) methyltransferase enzyme ... -
The role of the oxygen sensors PHD2 and PHD3 in the response of macrophages to ischemia-induced inflammation
(2016-12-12)Ischemic diseases, caused by the occlusion of a supplying blood vessel, result in a severe lack of oxygen and nutrients within the tissue. The ischemic insult triggers an inflammatory response of the innate immune system. ... -
Modulation of Cardiac Fibroblast to Myofibroblast Transition by Rho-Associated Kinases ROCK1 and ROCK2
(2016-10-25)Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. They play a critical role in the pathogenesis of myocardial fibrosis; however, their ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ... -
Basic leucine zipper and W2 domain-containing protein 2 (BZW2): A novel cardiac WNT component
(2016-02-11)Tight regulation of the Wnt/β-catenin pathway is crucial not only at all stages of embryonic cardiac development but also for maintaining normal adult heart homeostasis. Indeed, activation of the Wnt/β-catenin signaling ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ... -
Genetic polymorphisms in genes regulating renal ion excretion and diuretic drug effects
(2014-07-17)Regulation of human salt and fluid homeostasis is of basic biological importance. Kidney functions allow surviving under a wide variety of conditions with high or low salt diets and with high or low intake of fluids, even ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ...