Browse by type "doctoralThesis"
Now showing items 61-80 of 255
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The role of the receptor tyrosine kinase-like orphan receptors (RORs) in human breast cancer
(2022-12-05)Breast and colorectal cancers are among the most common tumor types worldwide and the occurrence of metastases is often associated with a shortened lifespan. One of the signaling pathways that has been frequently ... -
HID1 as a novel disease-causing gene in early onset neurological disorders: molecular, functional and phenotypic studies
(2022-09-07)Rare neurological diseases with genetic causes are gaining relevance for child morbidity and mortality due to improvements in health care, prevention and treatment of conventional life-limiting diseases in infants. Emerging ... -
Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ... -
The role of the Glucocorticoid Receptor in intestinal inflammation and tumorigenesis in a murine model of colitis and colitis-associated colorectal cancer
(2022-08-12)Ulcerative colitis (UC) is a life-threatening disease with constantly increasing incidence. Glucocorticoids (GCs) are one of the first choices for the treatment of this disease thanks to their anti-inflammatory action and ... -
Investigating the role of neutral sphingomyelinases in membrane vesicle trafficking
(2022-07-21)Evidence collected over the years has established small extracellular vesicle (sEV) or exosome secretion as a novel paradigm for intercellular communication under both physiological and pathological conditions. SEVs ... -
TP53-status dependent oncogenic EZH2 Activity in Pancreatic Cancer
(2022-07-14)Pancreatic Ductal Adenocarcinoma (PDAC) remains a dismal malignancy with a 5-year sur-vival rate of less than 10%. Predominately, chemoresistance mediated by the dynamic cel-lular plasticity induced through epigenetic ... -
Investigating how peripheral myelin-specific antibodies contribute to central nervous system demyelination – implications for future therapeutical approaches
(2022-07-14)The discovery of peripheral autoantibodies against myelin oligodendrocyte glycoprotein (MOG) allowed the delineation of MOG antibody-associated disease (MOGAD) from other central nervous system (CNS) demyelinating disorders, ... -
Studying the role of coenzyme Q10 in mitochondrial calcium and redox signaling
(2022-06-30)Mitochondria can take up large amounts of calcium (Ca2+) in order to control the activity of several enzymes and their bioenergetics output. As a consequence of this metabolic flux, reactive oxygen species (ROS) are generated ... -
Structure and molecular function of WD-40 repeat-containing autophagy proteins Atg18, Atg21 and Hsv2
(2022-06-23)Autophagy is a highly regulated cellular degradation and recycling process conserved from yeast to higher eukaryotes. This process is constitutively active at a low level, and non-selectively degrades portions of the cytosol ... -
Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
Analysis of the peroxisomal malate/aspartate and lactate/pyruvate shuttle components and their metabolic function
(2022-05-19)Peroxisomes are responsible for several metabolic processes. Among the best known functions are the breakdown of peroxides like H2O2 and the catabolism of fatty acids by α- and β-oxidation. The proper function of these ... -
Redox regulation of ryanodine receptor/Ca2+ release channels by NOX enzymes in hypertrophy and heart failure
(2022-05-10)Cardiac function is characterized by a rhythmic sequence of contraction and relaxation of cardiomyocytes driven by tightly controlled intracellular calcium release events. The cardiac ryanodine receptor type 2 calcium ... -
Peroxisomal calcium handling and homeostasis
(2022-04-26)Peroxisomes are ubiquitous cellular organelles in eukaryotes essential for metabolism. The close localization of peroxisomes with the sarcoplasmic reticulum and T-tubules is known from electron micrographs of rodent hearts. ... -
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
(2022-04-14)Melanoma is the deadliest of skin cancers and exhibits the highest level of brain tropism of all cancer types. Melanoma brain metastases (MBMs) are diagnosed in no less than 50 % of patients with stage IV melanoma, although ... -
Central nervous system intrinsic inflammation as driver and therapeutic target of progression in multiple sclerosis
(2022-01-25)Controlling disease progression in multiple sclerosis (MS) remains a major challenge. Progression of MS is defined as an increase in neurological disability occurring independently of relapses or focal MRI-detectable ... -
The role of CRISPLD1 in the transition to heart failure
(2022-01-21)Heart failure is a leading cause of death worldwide. It is defined as a condition in which the heart is unable to pump a sufficient amount of blood through the body to satisfy its oxygen need and can be caused by various ... -
Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ... -
GSK3β-mediated DNA damage repair in pancreatic cancer
(2021-11-24)In this study we aimed to determine a deeper mechanistic understanding of GSK3β and its influence on pancreatic cancer behavior. Specifically, we examined the effect of GSK3β on transcriptional regulation and function ... -
Overcoming Cisplatin Resistance in Pancreatic Cancer
(2021-11-16)Pancreatic ductal adenocarcinoma (PDAC) is the most common species of pancreatic cancer with high lethality. Despite intensive research, no major therapy improvements have been achieved due to late-stage diagnosis and ... -
Exploring the role of LZTR1 in an autosomal recessive form of Noonan Syndrome by genome-edited induced pluripotent stem cells
(2021-10-22)Noonan syndrome is a multisystemic developmental disorder and is characterized by variable symptoms such as facial dysmorphisms, short stature, webbing of the neck and mild intellectual disability. The most severe clinical ...