Browsing Molekulare Medizin by Author "Giansanti, Celeste"

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    • The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation 

      Giansanti, Celeste (2023-02-23)
      MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ...