Browsing Molekulare Medizin by Advisor & Referee "Alves, Frauke Prof. Dr."
Now showing items 1-20 of 22
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Pre-clinical assessment of the therapeutic efficacy of a nanovaccine in a mouse model of pancreatic cancer
(2024-08-09)Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases with increasing incidence in developed countries. Due to the late diagnosis of PDAC, available treatments do not significantly improve patient survival. ... -
3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
Functional and structural analysis approaches for translational lung disease research.
(2024-06-13)Respiratory ailments continue to pose a formidable challenge to public health. The respiratory system is a delicate interplay of muscle contraction, pressure gradients and a large surface area with thin diffusion barriers ... -
Fibroblasts in colorectal cancer: Subtype diversity and immune cell modulation
(2024-02-20)Despite significant advances in early detection and treatment, colorectal cancer (CRC) remains one of the deadliest cancers worldwide. In case of advanced disease, immunotherapies, such as immune checkpoint inhibitors ... -
Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
(2023-03-09)Microvascular dysfunction is a pathological hallmark of the diabetic myocardium, and is central to the etiology of diabetes-associated cardiac events. Herein, previous studies highlighted the role of the vasoactive micro-RNA ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
Cellular immunotherapy of pancreatic ductal adenocarcinoma: Discovery and evaluation of novel target candidates
(2021-03-19)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have achieved remarkable success in the ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Untersuchungen zur Chemotherapieresistenz von H8N8-Tumorzellen nach Cyclophosphamid-, Doxorubicin- und 5-Fluouraciltherapie im syngenen WAP-T-Mammakarzinom-Mausmodell
(2019-10-18)In breast cancer patients, it is usually not the primary tumor that is the cause of death, but rather the development of locoregional or distant recurrence. Despite seemingly complete resection, some tumor cells often ... -
Development and evaluation of new approaches for fluorescence-guided surgery and therapy of pancreatic ductal adenocarcinoma using orthotopic mouse models
(2017-07-11)Pancreatic cancer has the poorest survival rate of the most common types of cancers with a 5 year survival rate of only 3-5% after diagnosis. Since there has been no significant improvement in the clinical outcome for ... -
Airway Epithelial Cells as Targets of Glucocorticoid Therapy in Inflammatory Lung Diseases
(2017-02-24)Glucocorticoids (GCs) have been a mainstay in the treatment of various autoimmune and allergic diseases for many decades due to their potent anti-inflammatory activities. The beneficial effects of GCs are mediated by the ... -
Therapeutic strategies targeting Kv10.1 in PDAC
(2017-01-19)This study was conducted to explore the suitability of the voltage gated potassium channel Kv10.1 as a novel therapeutic target in pancreatic ductal adenocarcinoma (PDAC). PDAC, which is characterized by marked invasiveness, ... -
Charakterisierung induzierter, kolorektaler Lebermetastasen in einem Mausmodell und Einfluss von Makrophagenphänotypen auf die Tumorprogression
(2017-01-12)The liver is considered to be the primary target organ for hematogenous spread of colorectal cancer (CRC), as more than 50 % of affected patients develop liver metastases during the course of their tumor disease. Due to ... -
Induced pluripotent stem cells from patients with hypoplastic left heart syndrome (HLHS) as a model to study functional contribution of endothelial-mesenchymal transition (EndMT) in HLHS
(2016-11-30)Hypoplastic left heart syndrome (HLHS) is one of the most lethal congenital heart diseases (CHD) and its pathological mechanism remains unclear. Endocardial fibroelastosis (EFE) is a hallmark of HLHS which impairs myocardial ... -
The oxygen sensor PHD2 affects energy metabolism and cell function in macrophages
(2016-11-08)Macrophages are key players in the innate immune system and contribute significantly to inflammation in ischemic tissues, such as the infarcted heart. During inflammation, macrophages are involved in tissue remodeling, ... -
Analyse molekularer Marker und Signalwege in soliden Tumorzelllinien und ihre Bedeutung für die Tumorprogression und Metastasierung
(2016-06-01)The development of distant metastases is the main leading cause of cancer death and the crucial adverse event in cancer progression. The “Seed and Soil” hypothesis by Stephen Paget states that different cancer cells prefer ...