Browsing Molekulare Medizin by Advisor & Referee "Bastians, Holger Prof. Dr."
Now showing items 1-11 of 11
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Exploring new treatment strategies for mature T-cell neoplasms based on genetic alterations
(2024-09-10)Mature T-cell leukemias and lymphomas (mTCL) comprise a heterogeneous group of lymphoid malignancies that are generally associated with poor prognosis, low response to current standard therapy regimes and high relapse ... -
Impaired chromosome integrity caused by mutations in members of the BTRR complex
(2023-10-17)Bloom syndrome (BS) is an autosomal recessive rare disorder clinically characterized by primary microcephaly, growth deficiency, short stature, photosensitivity, immunodeficiency, and cancer predisposition. BS is caused ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
Investigating the Mechanistic role of Ykt6 in Wnt Trafficking and Cell cycle Progression
(2021-09-28)Ykt6 is an evolutionarily conserved R-SNARE that mediates vesicle fusion events at diverse cellular compartments of secretory, endocytic and autophagy pathways. It is known to be required for the secretion of Wnts on ... -
Aberrant CDK1 Activity in S Phase Induces Chromosomal Instability by Increasing Mitotic Microtubule Polymerisation Rates in Colorectal Cancer Cells
(2021-05-27)Whole chromosomal instability (W-CIN), one of the major hallmarks of human cancer, is defined as the perpetual gain or loss of whole chromosomes during mitosis leading to the development of heterogeneous karyotypes. W-CIN ... -
The Role of the Insulin-like Growth Factor Binding Protein 5 (IGFBP5) in Cardiogenesis and Cardiac Remodelling
(2018-10-15)The importance of elucidating mechanisms of cardiac regulatory networks during cardiogenesis is underscored by the re-activation of fetal gene expression in the diseased adult heart. To further understand this phenomenon, ... -
Hedgehog signaling in cutaneous squamous cell carcinoma
(2018-01-24)Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin tumor in humans with increasing incidence. cSCC is a result of malignant transformation of epidermal cells with ultraviolet (UV) radiation ... -
WNT signalling affects cell migration, invasion and the lymphoma-endothelial interplay in Hodgkin Lymphoma
(2016-06-23)Classical Hodgkin Lymphoma (cHL) comprises a unique cancer where the microenvironment accounts for 99 % of the whole tumour mass. In cHL dissemination involves functionally neighbouring lymph nodes but the underlying ... -
The role of Pygo2 during intestinal tumor initiation and progression in vivo
(2016-05-12)Canonical Wnt signaling pathway is an essential regulator of embryonic development as well homeostasis of adult tissues and stem cell proliferation. Familial or sporadic mutations of genes of Wnt signaling components are ... -
Analyses on the mechanisms underlying the leupaxin-mediated progression of prostate cancer
(2015-08-19)The focal adhesion protein leupaxin (LPXN) is overexpressed in a subset of prostate cancers (PCa). Recently, LPXN was shown to be involved in the progression of prostate carcinomas. In the present study, the LPXN-mediated ...