Browsing Molekulare Medizin by Advisor & Referee "Bogeski, Ivan Prof Dr."
Now showing items 1-6 of 6
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Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Differentiation-Induced Rearrangement of the Mitochondrial Calcium Uniporter Complex Regulates T-Cell-Mediated Immunity
(2023-01-20)CD4+ T-cells are an important cell type involved in proper mediation of the human adaptive immune system. Activation of CD4+ T-cells is a regulated process which includes a tightly controlled cytosolic calcium (Ca2+) ... -
Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ... -
Studying the role of coenzyme Q10 in mitochondrial calcium and redox signaling
(2022-06-30)Mitochondria can take up large amounts of calcium (Ca2+) in order to control the activity of several enzymes and their bioenergetics output. As a consequence of this metabolic flux, reactive oxygen species (ROS) are generated ... -
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
(2022-04-14)Melanoma is the deadliest of skin cancers and exhibits the highest level of brain tropism of all cancer types. Melanoma brain metastases (MBMs) are diagnosed in no less than 50 % of patients with stage IV melanoma, although ... -
Exploring molecular patterns and determinants of melanoma cell susceptibility to natural killer cell cytotoxicity
(2020-07-16)Malignant melanoma is the deadliest form of skin cancer. Due to its genetic heterogeneity and high potential to metastasize, the treatment of melanoma is challenging. Despite the promising result of T-cell based therapeutic ...