Browsing Molekulare Medizin by Advisor & Referee "Ehrenreich, Hannelore Prof. Dr. Dr."
Now showing items 1-7 of 7
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Characterizing immunomodulatory properties of a novel therapeutic approach for multiple sclerosis - Inhibition of Bruton's tyrosine kinase
(2024-05-06)Multiple Sclerosis is a complex and challenging chronic disease of the central nervous system (CNS), characterized by inflammation, demyelination, and neurodegeneration. The depletion of B cells using anti-CD20 antibodies ... -
Central nervous system intrinsic inflammation as driver and therapeutic target of progression in multiple sclerosis
(2022-01-25)Controlling disease progression in multiple sclerosis (MS) remains a major challenge. Progression of MS is defined as an increase in neurological disability occurring independently of relapses or focal MRI-detectable ... -
Cellular and transcriptional profiling of hypoxic cells in the brain
(2021-07-08)Hypoxia is a critical regulator of the hypoxic response driving neurodevelop-ment, angiogenesis, hematopoiesis, and tissue regeneration. In the central nervous system, oxygen is a fundamental constituent of cellular ... -
IFNβ as regulator of CD14/TLR4-mediated microglial responses to CNS infection and damage
(2017-02-15)Microglia are the innate immune cells of the central nervous system (CNS). They are capable of sensing infection and damage through various receptors and consequently trigger an appropriate immune response. This includes ... -
Constitutive heterogeneity and response diversity of microglia in pathological conditions
(2016-12-16)Microglia, resident myeloid cells of the CNS, execute an enormous variety of different functions like tissue surveillance, nursing of synapses, phagocytosis of foreign material or debris, and initiation of appropriate ... -
The role of amyloid beta 4-42 in the etiology of Alzheimer's disease
(2015-01-06)N-truncated Aβ4-42 has been identified as a particular abundant Aβ species in the hippocampus and cortex of Alzheimer's patients. However, relatively little is known about the contribution of Aβ4-42 to the development and ... -
Organization and consequences of functional responses in microglia upon activation of the TLR4 complex
(2014-09-30)Microglia are resident macrophage-like cells of the central nervous system (CNS) which constantly survey the tissue for signs of homeostatic disturbance. As the major immunocompetent effector cells in the brain parenchyma, ...