Browsing Molekulare Medizin by Advisor & Referee "Fischer, André Prof. Dr."
Now showing items 1-8 of 8
-
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
Cellular prion protein in Alzheimer’s disease: Molecular insights and behavior implications
(2024-01-11)Alzheimer’s disease (AD) poses a substantial and increasing challenge, particularly due to our aging population, and its underlaying pathophysiology remains a topic of ongoing debate. Cellular prion protein (PrPC) has ... -
Optimization of the RT-QuIC in prion disease diagnostic
(2023-01-11)In the present work, we were interested in applying different recombinant prion proteins (rec PrP) as substrates in the real-time quaking-induced conversion (RT-QuIC) assay to improve the diagnostic accuracy in different ... -
Gene-expression control in early and late-onset dementia
(2022-10-05)Mutations in genes that control epigenetic gene expression, especially the machinery that controls Histone 3 lysine 4 (H3K4me) methylation, are over-represented in intellectual disability disorders. It is mediated by both ... -
Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ... -
Engineered skeletal muscle from human pluripotent stem cells to model muscle disease and regeneration
(2021-06-25)Skeletal muscle disease modeling offers the unique opportunity to investigate devastating muscle diseases like Duchenne Muscle Dystrophy in vitro but requires advanced three-dimensional (3D) model systems reflecting the ... -
RNA methylation in Cardiac Hypertrophy and Heart Failure
(2020-11-06)Cardiovascular diseases (CVDs) are the leading cause of hospital admission and mortality worldwide. Heart failure (HF) is one of the most common CVDs and is characterized by a reduced cardiac function and left ventricular ... -
From Chromatin Readers to Heart Failure: BET Protein Family Members in Cardiac Remodeling
(2019-05-16)Heart failure (HF) is the pathologic inability of the heart to supply the body with sufficient amounts of oxygen-rich blood. This increasingly common, life-threatening condition occurs in the final stage of various cardiac ...