Browsing Molekulare Medizin by Advisor & Referee "Hanisch, Uwe-Karsten Prof. Dr."
Now showing items 1-7 of 7
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Functional proteome analysis of age associated PrPC knockout mice liver along with regulatory response of cytoskeleton associated tau protein and fatty liver disease.
(2015-12-03)PrPC is a membrane associated cellular glycoprotein. Its mis-folded form, PrPSc causes a set of neurodegenerative diseases called transmissible spongiform encephalopathies (TSEs). PrPC is abundantly expressed in the brain ... -
Establishing and application of a syngeneic cerebral metastasis mouse model
(2015-06-02)Metastases are a major cause of morbidity and mortality in breast cancer patients. However, current treatments are of limited efficiency because so far very little is known about the colonisation of breast cancer cells ... -
The role of membrane transporters in the pharmacokinetics of psychotropic drugs: in vitro studies with special focus on organic cation transporters
(2015-02-10)The treatment of common psychiatric disorders like major depression, schizophrenia and bipolar disorder is characterized by low efficacy and variability in the case of depression and bipolar disorder, and of undesirable ... -
Impact of N-terminally truncated Aß4-42 on memory and synaptic plasticity - Tg4-42 a new mouse model of Alzheimer's disease
(2015-01-14)A heterogeneous mixture of amyloid beta (Aβ) variants exists in Alzheimer’s disease (AD) brains. So far, little is known how individual Aβ species contribute to development and progression of this neurodegenerative disorder. ... -
The role of amyloid beta 4-42 in the etiology of Alzheimer's disease
(2015-01-06)N-truncated Aβ4-42 has been identified as a particular abundant Aβ species in the hippocampus and cortex of Alzheimer's patients. However, relatively little is known about the contribution of Aβ4-42 to the development and ... -
Extracellular vesicles as mediators of intercellular communication in human breast cancer progression
(2014-10-17)The establishment of a permissive tumor microenvironment is a key step for tumor progression and metastasis formation. Tumor cells are known for their ability to create such a favorable tumor niche by influencing the ... -
Organization and consequences of functional responses in microglia upon activation of the TLR4 complex
(2014-09-30)Microglia are resident macrophage-like cells of the central nervous system (CNS) which constantly survey the tissue for signs of homeostatic disturbance. As the major immunocompetent effector cells in the brain parenchyma, ...