Pancreatic ductal adenocarcinoma (PDAC) presents significant therapeutic challenges due to its pronounced tumor heterogeneity and complex metabolic reprogramming within the tumor microenvironment. In this study, advanced ...

Based on a high degree of cellular plasticity and triggered by external (e.g. inflammation) or internal (e.g. oncogenic pressure) signals, pancreatic acinar cells can undergo reprogramming processes resulting in acinar-to-ductal ...