Browsing Molekulare Medizin by Advisor & Referee "Lehnart, Stephan E. Prof. Dr."
Now showing items 1-6 of 6
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Mild production of reactive oxygen species reversibly affects the metabolism and function of the heart
(2023-01-25)Reactive oxygen species (ROS) are molecular oxygen derivatives that are produced as an attribute of aerobic life. The relationship between elevated levels of ROS and heart failure (HF) has been extensively studied. However, ... -
Redox regulation of ryanodine receptor/Ca2+ release channels by NOX enzymes in hypertrophy and heart failure
(2022-05-10)Cardiac function is characterized by a rhythmic sequence of contraction and relaxation of cardiomyocytes driven by tightly controlled intracellular calcium release events. The cardiac ryanodine receptor type 2 calcium ... -
Novel protein-protein interactions contribute to the regulation of cardiac excitation and Ca2+ handling
(2021-02-01)Cardiac function is defined by the process of excitation and contraction. During this process, the electrical excitation of the surface membrane is coupled to Ca2+-ion release at the sarcoplasmic reticulum, resulting in ... -
Phospholamban - Identification of novel interaction partners
(2020-07-24)Cardiac contraction and relaxation depend on intracellular Ca2+ release and sequestration in the sarcoplasmic reticulum (SR). The small tail-anchored protein phospholamban (PLN) is essential for normal stress-adaptation ... -
Application of redox biosensor mouse models to study redox processes in cardiomyocytes
(2019-08-08)Reactive oxygen species (ROS) are highly reactive molecules produced in any biological system. When ROS are produced in higher amounts, they are lethal to cells. Therefore cells possess a tight redox regulation through ... -
Examining the interplay between oxidative and β-adrenergic regulation of PKARIα and its impact on the mitochondrial fission protein DRP1
(2017-07-03)PKA is activated by β-adrenergic signaling induced elevation in intracellular cAMP and sequestered into proximity with its substrates by scaffold A-kinase anchoring proteins (AKAPs). PKARIα is a unique isoform of PKA as ...