Browsing Molekulare Medizin by Advisor & Referee "Nikolaev, Viacheslav Dr."
Now showing items 1-7 of 7
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Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice
(2015-01-26)cAMP and cGMP are important second messengers in the cardiovascular system. Previously, it has been demonstrated that the cardiac ryanodine receptor (RyR2) forms a microdomain associated with key contributors of cAMP ... -
Die Rolle der Phosphodiesterase 2 im Herzen
(2014-12-03)Heart failure is a worldwide health issue with high morbidity and mortality rates and always a poor prognostic outlook. A characteristic element of the molecular driven structural transformation, which precedes the ... -
Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease
(2014-11-13)Cyclic nucleotides are ubiquitous second messengers, which regulate cellular functions by acting in discrete subcellular microdomains. Cardiac phosphodiesterases (PDEs) are indispensable for -adrenoceptor signaling regulation ... -
Local cAMP dynamics in the SERCA2a signalling complex
(2014-11-13)3’,5’-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that regulates multiple physiological functions by acting in distinct subcellular microdomains. Over the last few years, several targeted biosensors ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ...