Browsing Molekulare Medizin by Advisor & Referee "Nikolaev, Viacheslav Prof. Dr."
Now showing items 1-6 of 6
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Crosstalk of macrophages and endothelial cells in endothelial-to-mesenchymal transition and cardiac fibrosis
(2017-07-27)Cardiac fibrosis (CF) is an integral component of virtually all forms of chronic cardiac disease. CF manifests as an accumulation of excessive extracellular matrix (ECM) components throughout the myocardium. Aberrant ... -
Examining the interplay between oxidative and β-adrenergic regulation of PKARIα and its impact on the mitochondrial fission protein DRP1
(2017-07-03)PKA is activated by β-adrenergic signaling induced elevation in intracellular cAMP and sequestered into proximity with its substrates by scaffold A-kinase anchoring proteins (AKAPs). PKARIα is a unique isoform of PKA as ... -
Development of a genetically encoded model for the sensing of glutathione redox potential in human embryonic stem cell-derived cardiomyocytes and fibroblasts
(2017-05-29)Redox alterations due to increased ROS production in heart cells have been implicated in several cardiovascular diseases, such as ischemia, hypertrophy, and myocardial infarction, but may also play a crucial role for the ... -
Functional analysis of ryanodine receptor 2 mutations in induced pluripotent stem cell-derived cardiomyocytes from CPVT patients
(2017-03-30)Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an ion channel disorder in the heart, which is characterized by abnormal calcium handling, ventricular arrhythmias, and sudden cardiac death. This inherited ... -
Real time cAMP dynamics in the vicinity of phospholemman in healthy and failing cardiomyocytes
(2016-08-16)The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is a crucial regulator of cardiac function and disease. It is known that cAMP signaling is mediated by discrete functional microdomains each ... -
Basic leucine zipper and W2 domain-containing protein 2 (BZW2): A novel cardiac WNT component
(2016-02-11)Tight regulation of the Wnt/β-catenin pathway is crucial not only at all stages of embryonic cardiac development but also for maintaining normal adult heart homeostasis. Indeed, activation of the Wnt/β-catenin signaling ...