Browsing Molekulare Medizin by Advisor & Referee "Oppermann, Martin Prof. Dr."
Now showing items 1-4 of 4
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MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Induced pluripotent stem cell-derived cardiomyocytes as model for studying CPVT caused by mutations in RYR2
(2016-12-02)Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary cardiac ion-channel disease, which is caused by mutations in ryanodine receptor 2 (RYR2) or calsequestrin 2 (CASQ2). After β-adrenergic ... -
Physiological and molecular features of glucocorticoid actions in the gastrointestinal tract
(2015-04-14)Ever since their first successful application in the treatment of RA patients in the late 1950, GCs have been the gold standard for the treatment of multiple inflammatory and neoplastic diseases. There are, however, also ... -
Chemokine receptors CXCR4 and CCR5: Cell surface expression, signaling and modulation by β-arrestin 2
(2015-02-26)G protein-coupled receptors which mediate a large variety of different cellular effects have always been a field of significant interest for pharmaceutical research. Since it was shown that the chemokine receptors CXCR4 ...