Browsing Molekulare Medizin by Advisor & Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 1-10 of 10
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Long-term Replacement of Endogenous Microglia in Mice
(2024-12-19)Microglia are the resident immune cells of the central nervous system (CNS). They play pivotal roles in the development and homeostasis of the CNS and have been implicated in neurodegenerative disorders, such as Alzheimer´s ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
Cellular prion protein in Alzheimer’s disease: Molecular insights and behavior implications
(2024-01-11)Alzheimer’s disease (AD) poses a substantial and increasing challenge, particularly due to our aging population, and its underlaying pathophysiology remains a topic of ongoing debate. Cellular prion protein (PrPC) has ... -
Alpha-synuclein-associated alterations at the synapse in models of Parkinson’s disease
(2023-08-16)Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is characterized by the typical motor features, and also by a multiplicity of non-motor symptoms. The main pathological hallmarks of PD ... -
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
BAX and BAK - the deadly rings. A comprehensive study of the mitochondrial apoptotic pore in situ with super-resolution microscopy
(2023-02-23)Apoptosis, the most common form of cell death in the human body, is essential for numerous physiological processes. The intrinsic apoptosis pathway can be triggered by a wide variety of stimuli and leads to the insertion ... -
Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
Cellular and transcriptional profiling of hypoxic cells in the brain
(2021-07-08)Hypoxia is a critical regulator of the hypoxic response driving neurodevelop-ment, angiogenesis, hematopoiesis, and tissue regeneration. In the central nervous system, oxygen is a fundamental constituent of cellular ... -
Emerging role of RNA-binding proteins in sporadic and rapid progressive Alzheimer’s disease
(2020-04-07)Alzheimer’s disease (AD) is the most prevalent cause of dementia. Typically, AD is characterized as a slow progressive dementia with an average disease duration of eight years. Recently, a rapidly progressive variant of ... -
Seeding and structural varibility in α-synucleinopathies
(2019-06-12)In the present work, we were interested in applying the Real-time quaking-induced conversion (RT-QuIC) for the detection of the seeding activity of Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) brain derived ...