Browsing Molekulare Medizin by Advisor & Referee "Rehling, Peter Prof. Dr."
Now showing items 1-6 of 6
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Atrial mitochondrial calcium handling in patients with atrial fibrillation
(2023-05-30)Atrial fibrillation (AF) is the most common form of arrhythmia however, due to the incomplete understanding of its molecular mechanisms, there are several limitations of the currently available therapeutic strategies. ... -
Phospholamban - Identification of novel interaction partners
(2020-07-24)Cardiac contraction and relaxation depend on intracellular Ca2+ release and sequestration in the sarcoplasmic reticulum (SR). The small tail-anchored protein phospholamban (PLN) is essential for normal stress-adaptation ... -
Role of MICOS for mitochondrial morphology and function
(2019-12-17)Mitochondria are highly dynamic organelles with a distinct morphological membrane ultrastructure. The mayor protein complex responsible for the formation and maintenance of the inner mitochondrial membrane is the ... -
Analysis of the role of Cox20 during the early steps of Cox2 biogenesis
(2016-08-24)The catalytic core of the cytochrome c oxidase (complex IV), the terminal enzyme of the mitochondrial respiratory chain, comprises three mitochondria-encoded subunits Cox1, Cox2 and Cox3 that are highly conserved among ... -
Control of cardiogenesis and homeostasis by cardiac fibroblasts
(2016-07-12)The mammalian heart is a complex multicellular organ which undergoes many critical changes during development and under pathological conditions. Cardiac fibroblasts (cFBs) represent the predominant non-myocyte population ... -
Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice
(2015-01-26)cAMP and cGMP are important second messengers in the cardiovascular system. Previously, it has been demonstrated that the cardiac ryanodine receptor (RyR2) forms a microdomain associated with key contributors of cAMP ...