Browsing Molekulare Medizin by Advisor & Referee "Reichardt, Holger Prof. Dr."
Now showing items 1-19 of 19
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Subcellular compartmentalization of signal elements and their re-distribution in resting and activated B cells
(2024-09-19)BCR activation triggers a complex network of pathways and cascades, shaping the fate of B cells. This process is influenced by co-receptors as well as co-stimulatory molecules, among others. Dysregulation in this process ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Novel therapeutic approaches to treat inflammatory conditions with glucocorticoid and calciferol nanoparticles in vivo and in vitro
(2023-01-10)The body is constantly confronted with environmental threats and sometimes the entry of pathogens leads to severe inflammatory conditions such as sepsis or acute lung injury (ALI). Both diseases are characterized by a ... -
Investigating how peripheral myelin-specific antibodies contribute to central nervous system demyelination – implications for future therapeutical approaches
(2022-07-14)The discovery of peripheral autoantibodies against myelin oligodendrocyte glycoprotein (MOG) allowed the delineation of MOG antibody-associated disease (MOGAD) from other central nervous system (CNS) demyelinating disorders, ... -
TNFα-mediated subtype switch and tumor progression in pancreatic cancer
(2021-09-30)Pancreatic cancer (PDAC) represents an extremely poor clinical outcome with a 5-year survival rate of <9%. It is anticipated to become the second leading cause of cancer-related deaths in the industrialized countries by ... -
HSP90-stabilized proteins as therapeutic targets in cancer
(2021-06-25)Although cancer is among the most common causes of death worldwide, successful treatment options for most cancer entities remain elusive, raising the need for novel therapies. One attractive target of current drug candidates ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
The Role of Glycolysis in shaping the Autoimmune Potential of Myelin-Reactive T Cells in the Course of Experimental Autoimmune Encephalomyelitis
(2019-10-11)Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), where myelin-reactive T cells play a key role in the inflammatory events responsible for the formation of demyelinated lesions. Auto-reactive ... -
Quantitative Proteomics Analysis of Global Protein Expression in Campylobacter jejuni Cultured in Sublethal Concentrations of Bile Acids and Varying Temperatures
(2017-07-06)Campylobacter jejuni is the leading cause of diarrhoea among human beings worldwide. Epidemiological investigations have shown that it affects over 500 million people per year. C. jejuni is mainly transmitted to human ... -
Airway Epithelial Cells as Targets of Glucocorticoid Therapy in Inflammatory Lung Diseases
(2017-02-24)Glucocorticoids (GCs) have been a mainstay in the treatment of various autoimmune and allergic diseases for many decades due to their potent anti-inflammatory activities. The beneficial effects of GCs are mediated by the ... -
The role of the oxygen sensors PHD2 and PHD3 in the response of macrophages to ischemia-induced inflammation
(2016-12-12)Ischemic diseases, caused by the occlusion of a supplying blood vessel, result in a severe lack of oxygen and nutrients within the tissue. The ischemic insult triggers an inflammatory response of the innate immune system. ... -
Myeloid corticoid receptors in CNS autoimmunity: Old targets for novel therapies
(2016-10-21)Since the 1950s, glucocorticoids (GCs) have been the most widely employed drugs in the treatment of inflammatory and autoimmune disorders, such as multiple sclerosis (MS). Short-time application of high-dose GCs is the ... -
Identification of genes regulated in target organs of acute graft versus host disease in different organs in different species
(2016-10-13)Major histocompatibility complex (MHC) matching is essential to reduce the risk of graft versus host disease (GvHD) but minor histocompatibility antigens (mHags) also affect the outcome of hematopoietic stem cell transplantation ... -
New approaches to improve Extracorporeal Photopheresis for the treatment of Graft-versus-Host Disease
(2016-05-25)Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity ... -
Immunopathogenesis of cortical demyelination in Multiple Sclerosis
(2015-11-20)Cortical demyelination is a key pathological feature of multiple sclerosis (MS) and clinically linked to cognitive deficits and disability progression. Extensive band-like subpial demyelination is even a specific feature ... -
Ex vivo und in vivo Modulation von Makrophagen und T-Zellen als therapeutisches Prinzip der aGvHD
(2015-10-15)Acute Graft-versus-Host disease (aGvHD) is a severe complication of hematopoietic stem cell transplantation. Glucocorticoids (GCs) are a mainstay of aGvHD therapy due to their potent anti-inflammatory and immunosuppressive ... -
Importance of CXCL12 and CXCR4 in radiotherapy of head and neck cancer, considering the association with HPV-infection
(2015-09-10)p16INK4A expression is an important, independent prognostic marker in HNSCC patients. We observed a strong correlation between tumour HPV status, particularly HPV-16, and p16INK4A expression. Accordingly, our data clearly ... -
Analyzing the effects of laquinimod on innate and adaptive immunity in mice with experimental autoimmune encephalomyelitis
(2014-05-09)Laquinimod (LAQ), a new orally active immunomodulator, is currently under investigation for the treatment of multiple sclerosis (MS). In clinical trials LAQ considerably reduced the annualized relapse rate, disability ... -
Migratory Cues For Encephalitogenic Effector T Cells Within The CNS During The Different Phases Of EAE
(2013-06-17)In multiple sclerosis (MS), encephalitogenic T cells are considered to breach distinct cerebral barriers in order to gain access to their target tissue, the CNS. However, it remains poorly understood exactly how auto-reactive ...