Browsing Molekulare Medizin by Advisor & Referee "Schwappach, Blanche Prof. Dr."
Now showing items 1-15 of 15
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In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
Identification and Characterization of autophagic and non-autophagic Interaction Partners of Atg18
(2021-06-03)The PROPPIN Atg18 belongs to the WD40 repeat containing family and folds into a typical seven-bladed beta-propeller. Conserved regions at blade 5 and 6 allow for binding to phosphatidylinositolphosphates and mediate the ... -
The role of NARF and other novel progeria-associated genes/proteins in ageing processes.
(2021-01-29)The world’s population is ageing rapidly. Currently, people at the age of 60 and over represent 12.3% of the global population. By 2050, this number will rise to almost 22%. Our knowledge of ageing underlying processes is ... -
An integrative and translational assessment of altered atrial electrophysiology, calcium handling and contractility in patients with atrial fibrillation
(2020-11-18)Atrial fibrillation (AF) is the most prevalent sustained arrhythmia reported in clinical practice, and it is associated with deleterious outcomes such as stroke, that increase patient morbidity and mortality. Previous ... -
Application of redox biosensor mouse models to study redox processes in cardiomyocytes
(2019-08-08)Reactive oxygen species (ROS) are highly reactive molecules produced in any biological system. When ROS are produced in higher amounts, they are lethal to cells. Therefore cells possess a tight redox regulation through ... -
New Insights into Nucleophagy in S. cerevisiae
(2019-03-12)Nucleophagy is a specific type of autophagy, a process for the degradation of non-essential parts of the nucleus under starvation conditions. Nucleophagy can be subdivided into Atg39 and Atg40 dependent macronucleophagy ... -
Exosomes as Potential Transport Vehicles of Tetrahydrobiopterin, 6-Pyrovyoltetrahydrobiopterin-Synthase and Tripeptidyl-Peptidase I
(2018-12-14)Extracellular vesicles (EV) for the therapeutic application are of growing scientific interest. But even though the number of clinical trials on EVs almost doubled from 29 to 52 within 2017, the number of trials with ... -
Development and evaluation of new approaches for fluorescence-guided surgery and therapy of pancreatic ductal adenocarcinoma using orthotopic mouse models
(2017-07-11)Pancreatic cancer has the poorest survival rate of the most common types of cancers with a 5 year survival rate of only 3-5% after diagnosis. Since there has been no significant improvement in the clinical outcome for ... -
Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Expression von Aufnahme-Transportern für Zytostatika in Mamma- und Prostatakarzinom-Zellen und ihre Interaktion mit Zytostatika
(2017-06-27)The solute carrier (SLC) transporters form a large family of membrane proteins that translocate dissolved substances across cell membranes. The first part of this work investigates the interaction of 26 commonly used ... -
Real time cAMP dynamics in the vicinity of phospholemman in healthy and failing cardiomyocytes
(2016-08-16)The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is a crucial regulator of cardiac function and disease. It is known that cAMP signaling is mediated by discrete functional microdomains each ... -
Dissecting molecular elements of mitophagy and the lysis of intravacuolar vesicles
(2015-10-26)Autophagy is an evolutionary conserved catabolic process essential for the recycling and removal of cytosolic components via the lysosome (vacuole). Macroautophagy is characterized by the formation of a double membrane-layered ... -
Role of Secretory Processes in Cardiac Fibroblasts for Heart Failure Development and Progression
(2014-11-27)Cardiac fibroblasts play a major role in fibrogenesis associated with heart failure, since they produce ECM components and secrete important fibrosis-associated mediators, such as connective tissue growth factor (CTGF). ... -
Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease
(2014-11-13)Cyclic nucleotides are ubiquitous second messengers, which regulate cellular functions by acting in discrete subcellular microdomains. Cardiac phosphodiesterases (PDEs) are indispensable for -adrenoceptor signaling regulation ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ...